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Cat. No.: HY-185799

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BL4-5

BL4-5 is a branched linker intermediate of antibody-drug conjugate linkers (ADC Linkers), which is applicable to research related to ADC synthesis.

For research use only. We do not sell to patients.

CAS No.: 2758876-17-2
Formula: C₄₁H₇₈N₁₀O₁₇
Molecular Weight:983.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (261 KB)

BL4-5 Chemical Structure

CAS No.: 2758876-17-2

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

BL4-5 is a branched linker intermediate of antibody-drug conjugate linkers (ADC Linkers), which is applicable to research related to ADC synthesis^[1].

All ADC Linkers Isoforms :

In Vitro

BL4-5 (Example 17B) is synthesized from BL4-3 and BL2-4 in DMF at 25 °C to yield the small-molecule linker intermediate BL4-5^[1].
BL4-5 undergoes deprotection with 4 M hydrochloric acid in methanol at 25 °C to afford the branched linker BL4^[1] in 33% yield.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2758876-17-2
Molecular Weight 983.11
Formula C₄₁H₇₈N₁₀O₁₇
SMILES

[N-]=[N+]=NCCOCCOCCOCCNC(CCOCC(COCCC(NCCOCCOCCOCCN=[N+]=[N-])=O)NC(CCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Han A. Camptothecin analogs conjugated to a glutamine residue in a protein, and their use. WO2022015656 A1. WIPO. 2022.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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