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Cat. No.: HY-172982

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CTW0419

CTW0419 is a 5-HT_2A receptor positive allosteric modulator (PAMs). CTW0419 allosterically modulates 5-HT2A receptor signaling, enhances the functional response to orthosteric ligands, and enhances serotonin-induced intracellular calcium release. CTW0419 attenuates (-)-DOI-induced head-twitch response. CTW0419 can be used in research related to neuropsychiatric disorders.

For research use only. We do not sell to patients.

Formula: C₁₇H₂₆N₂O₃
Molecular Weight:306.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CTW0419 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All 5-HT Receptor Isoforms :

In Vitro

CTW0419 acts as a positive allosteric modulator of 5-HT_2A in cells expressing h5-HT_2A, enhancing 5-HT-induced calcium release without intrinsic agonist activity, and shows no activity at h5-HT_2B or h5-HT_2C^[3].
CTW0419 shows minimal binding to off-target CNS receptors in secondary competitive binding assays^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CTW0419 does not substitute for the (-)-DOI discriminative cue, does not induce head-twitch responses in male Sprague-Dawley rats, and attenuates (-)-DOI-induced head-twitch responses^[3].
CTW0419 is detectable in rat brain distribution^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 306.40
Formula C₁₇H₂₆N₂O₃
SMILES

O=C(C1CC(CCN1)CCC2=CC=CC=C2)NCC(CO)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bolinger A A, et al. The serotonin 5-HT2A receptor as an evolving neurotherapeutic target[J]. 2023.

[2]. Ali S, et al. Targeting the 5-HT2A receptor for developing psychedelic drugs and beyond[J]. Journal of medicinal chemistry, 2025, 68(10): 9831.

[3]. Zamora J C, et al. Serendipitous Discovery of Novel 5-HT2AR Positive Allosteric Modulators (PAMs) Derived From 5-HT2CR PAM Scaffolds[J]. The Journal of Pharmacology and Experimental Therapeutics, 2024, 389: 87.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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