FARSA - phenylalanyl-tRNA synthetase subunit alpha Gene

Also Known as FRSA; CML33; FARSL; PheHA; FARSLA; RILDBC2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2193

About FARSA

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,922,479-12,933,711 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 24.2), lymph node (RPKM 16.8) and 25 other tissues.

Summary

Aminoacyl-tRNA synthetases are a class of Enzymes that charge tRNAs with their cognate Amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]

FARSA Products (1)

mRNA Protein Name
NM_004461.3 NP_004452.1 phenylalanine--tRNA ligase alpha subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phenylalanine-tRNA ligase activity IDA
IDA: Inferred from direct assay
20223217 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20223217 GOA
Biological Process GO Annotation Evidence References Source
involved in phenylalanyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
20223217 GOA
involved in protein heterotetramerization IDA
IDA: Inferred from direct assay
20223217 GOA
Cellular Component GO Annotation Evidence References Source
part of phenylalanine-tRNA ligase complex IDA
IDA: Inferred from direct assay
20223217 GOA
part of phenylalanine-tRNA ligase complex IPI
IPI: Inferred from physical interaction
20223217 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FARSA Protein Structure

tRNA-synt_2d

tRNA-synt_2d: tRNA synthetases class II core domain (F) (210 - 483)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

phenylalanine--tRNA ligase alpha subunit

  • pheRS

FARSA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
Anti Tag CoIP
33961781
Intra
FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
Pull Down
20223217
Intra
FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
Y2H Prey Pooling
32296183
Intra
FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
GMS
20223217
Intra
FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
X-Ray Diffraction
20223217
Intra
FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
Y2H Array
32296183
Intra
FARSA Q9Y285 FARSB Homo sapiens Q9NSD9
Anti Tag CoIP
28514442
Intra
FARSA Q9Y285 COG4 Homo sapiens Q9H9E3
Y2H Prey Pooling
32296183
Intra
FARSA Q9Y285 COG4 Homo sapiens Q9H9E3
Y2H Array
32296183
Intra
FARSA Q9Y285 ECSIT Homo sapiens Q9BQ95
Pull Down
21163940
Intra
FARSA Q9Y285 PDCD10 Homo sapiens Q9BUL8
Y2H Prey Pooling
32296183
Intra
FARSA Q9Y285 PDCD10 Homo sapiens Q9BUL8
Y2H Array
32296183
Intra
FARSA Q9Y285 ABI3 Homo sapiens Q9P2A4
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rajab Interstitial Lung Disease With Brain Calcifications 2

  • RILDBC2
Interstitial Lung Disease

  • Ild

  • Lung Diseases, Interstitial

  • Lung Diseases Interstitial

  • Interstitial Lung Diseases
Liver Disease

  • Liver Failure

  • Liver Diseases

  • Abnormality Of The Liver

  • Liver Dysfunction

  • Disorder Of Liver

  • Hepatic Disorder

  • Hepatic Disease

  • Disease Of Bilirubin Metabolism

  • Disorder Of Bilirubin Metabolism

  • Liver Decompensation

  • Liver Function Failure

  • Hepatic Failure Nos

  • Liver Failure Nos

  • End Stage Liver Disease

  • Decompensated Liver Failure

  • Decompensation Of Liver Function

  • Hepatic Decompensation

  • Hepatic Insufficiency

  • Liver Cell Necrosis With Hepatic Failure

  • Liver Insufficiency

  • Decompensated Liver Disease

  • End Stage Liver Failure

  • Liver Necrosis With Hepatic Failure
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04749 FARSA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FARSA RGD RGD:1310314
Macaca mulatta FARSA VGNC VGNC:72615
Felis catus FARSA VGNC VGNC:62151
Mus musculus FARSA MGD MGI:1913840
Bos taurus FARSA VGNC VGNC:28867
Canis familiaris FARSA VGNC VGNC:40733
Others FARSA NCBI