PTPN22 - protein tyrosine phosphatase non-receptor type 22 Gene

Also Known as LYP; PEP; LYP1; LYP2; PTPN8; PTPN22.5; PTPN22.6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26191

About PTPN22

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:113,813,811-113,871,759 (from NCBI)

This gene has 11 transcripts (splice variants), 125 orthologues, 35 paralogues and is associated with 9 phenotypes. Biased expression in bone marrow (RPKM 9.6), lymph node (RPKM 7.9) and 13 other tissues.

Summary

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine Phosphatase family. The encoded protein is a lymphoid-specific intracellular Phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]

PTPN22 Products (4)

mRNA	Protein	Name
NM_001193431.2	NP_001180360.1	tyrosine-protein phosphatase non-receptor type 22 isoform 3
NM_001308297.1	NP_001295226.1	tyrosine-protein phosphatase non-receptor type 22 isoform 4
NM_012411.5	NP_036543.4	tyrosine-protein phosphatase non-receptor type 22 isoform 2
NM_015967.8	NP_057051.4	tyrosine-protein phosphatase non-receptor type 22 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatase activity	IDA IDA: Inferred from direct assay	23991106	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10068674	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	10068674	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	23871208	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to muramyl dipeptide	IDA IDA: Inferred from direct assay	23991106	GOA
involved in lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23991106	GOA
involved in negative regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	23991106	GOA
involved in negative regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	18299186	GOA
involved in negative regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	18056643	GOA
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	23991106	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23991106	GOA
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	23991106	GOA
involved in negative regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	23991106	GOA
involved in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	23991106	GOA
involved in negative regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	23991106	GOA
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	23991106	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23991106	GOA
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	27043286	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23871208	GOA
involved in positive regulation of protein K63-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	23871208	GOA
involved in positive regulation of toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	23871208	GOA
involved in positive regulation of toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	23871208	GOA
involved in positive regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	23871208	GOA
involved in positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	23991106	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	10068674	GOA
involved in regulation of natural killer cell proliferation	IDA IDA: Inferred from direct assay	20522204	GOA
involved in regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	23991106	GOA
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	23871208	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10068674	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	10940933	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10940933	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10068674	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN22 Protein Structure

Y_phosphatase

0
200
400
600
807 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein phosphatase non-receptor type 22	PEST-domain phosphatase

PTPN22 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTPN22	Q9Y2R2	PSTPIP1	Homo sapiens	O43586	Anti Tag CoIP	25040622
Intra	PTPN22	Q9Y2R2	CD247	Homo sapiens	P20963	Pull Down	16461343
Intra	PTPN22	Q9Y2R2	CD247	Homo sapiens	P20963	Anti Tag CoIP	16461343
Intra	PTPN22	Q9Y2R2	ZAP70	Homo sapiens	P43403	Pull Down	16461343
Intra	PTPN22	Q9Y2R2	ZAP70	Homo sapiens	P43403	Phosphatase Assay	16461343
Intra	PTPN22	Q9Y2R2	LCK	Homo sapiens	P06239	Phosphatase Assay	19167335
Intra	PTPN22	Q9Y2R2	LCK	Homo sapiens	P06239	Phosphatase Assay	16461343
Intra	PTPN22	Q9Y2R2	LCK	Homo sapiens	P06239	Pull Down	16461343
Intra	PTPN22	Q9Y2R2	LCK	Homo sapiens	P06239	Phosphatase Assay	21719704
Intra	PTPN22	Q9Y2R2	SKAP2	Homo sapiens	O75563	X-Ray Diffraction	21719704
Intra	PTPN22	Q9Y2R2	SKAP2	Homo sapiens	O75563	Anti Tag CoIP	21719704
Intra	PTPN22	Q9Y2R2	EGFR	Homo sapiens	P00533	Lumier	24658140
Intra	PTPN22	Q9Y2R2	TRAF3	Homo sapiens	Q13114	Anti Bait CoIP	23871208
Intra	PTPN22	Q9Y2R2	GRB2	Homo sapiens	P62993	Anti Bait CoIP	11882361
Intra	PTPN22	Q9Y2R2	GRB2	Homo sapiens	P62993	Phage Display	11882361
Cross	PTPN22	Q9Y2R2	Traf3	Mus musculus	Q60803	Anti Tag CoIP	23871208
Cross	PTPN22	Q9Y2R2	Traf3	Mus musculus	Q60803	Pull Down	23871208

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 6	Vitiligo Generalized Vitiligo VAMAS6 VTLG Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1
Hypoadrenocorticism, Familial	Addison Disease Primary Adrenocortical Insufficiency Addison'S Disease Adrenal Gland Hypofunction Adrenal Hypoplasia Adrenal Aplasia Addison Disease, Chronic Adrenal Insufficiency Primary Hypoadrenalism Hypoadrenocorticism Familial Autoimmune Addison Disease Autoimmune Adrenalitis Classic Addison Disease Primary Addison Disease Addisons Disease Addison Disease, Susceptibility To Autoimmune Primary Adrenal Insufficiency Addison'S Disease Due To Autoimmunity
Vogt-Koyanagi-Harada Disease	Uveomeningoencephalitic Syndrome Uveomenigitic Syndrome Vogt-Koyanagi-Harada Syndrome Harada'S Disease Vogt-Koyanagi Syndrome Vkh Disease Vkh Syndrome Vkh
Temporal Arteritis	Polymyalgia Rheumatica Giant Cell Arteritis Cranial Arteritis Horton Disease Gca Horton'S Disease Rhizomelic Pseudopolyarthritis Arteritis Cranialis Arteritis Temporalis Horton'S Arteritis Horton'S Giant Cell Arteritis Horton'S Temporal Arteritis Horton'S Syndrome Gca - [Giant Cell Arteritis] Senile Arthritis Polymyalgia Arteritica Pmr - [Polymyalgia Rheumatica] Forestier-Certonciny Syndrome Rheumatic Polymyalgia Polymyalgia
Hashimoto Thyroiditis	Autoimmune Thyroiditis Hashimoto Struma Hashimoto'S Thyroiditis Chronic Lymphocytic Thyroiditis Lymphocytic Thyroiditis Hashimoto Disease Ht Hashimoto'S Disease Hashimoto'S Syndrome Hypothyroidism, Autoimmune Autoimmune Chronic Lymphocytic Thyroiditis Chronic Lymphocytic Thyroiditides Hashimoto Syndrome Hashimotos Thyroiditis Hashimoto Thyroiditis, Susceptibility To Thyroiditis, Autoimmune Lymphomatous Thyroiditis Lymphoid Thyroiditis Chronic Lymphadenoid Thyroiditis Autoimmune Lymphocytic Chronic Thyroiditis Goitre Lymphomatosa Hashitoxicosis Hashimoto Hypothyroidism Lymphadenoid Goitre Struma Lymphomatosa Hyperthyroidism With Hashimoto Disease Hashimoto Thyrotoxicosis Thyrotoxicosis Due To Hashimoto Thyroiditis Struma Lymphomatosis Lymphadenoid Struma
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Graves' Disease	Graves Disease Exophthalmic Goiter Basedow'S Disease Grave'S Disease Basedow Disease Toxic Diffuse Goiter Graves' Hyperthyroidism Parry Disease Autoimmune Hyperthyroidism Toxic Multinodular Goiter
Oligoarticular Juvenile Idiopathic Arthritis	Oligoarticular Jia Pauciarticular Chronic Arthritis Juvenile Pauciarticular Chronic Arthritis
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis	Juvenile Polyarthritis Without Rheumatoid Factor Juvenile Rheumatoid Factor-Negative Polyarthritis Rheumatoid Factor-Negative Polyarticular Jia Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Scleritis
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1	Vitiligo VAMAS1 Slev1 Vtlg Systemic Lupus Erythematosus, Vitiligo-Related Vitiligo-Associated Multiple Autoimmune Disease 1 Systemic Lupus Erythematosus Vitiligo-Related
Alopecia Areata	Aa Alopecia Celsi Alopecia Circumscripta Cazenave'S Vitiligo Celsus' Vitiligo Diffuse Alopecia Jonston'S Alopecia Marginal Alopecia Pseudopelade Circumscribed Alopecia Alopecia Cicatrisata Patchy Alopecia Alopecia Aa - [Alopecia Areata] Pelade
Type 1 Diabetes Mellitus 5	Diabetes Mellitus, Insulin-Dependent, 5 Latent Autoimmune Diabetes In Adults IDDM5 Insulin-Dependent Diabetes Mellitus 5 T1D5 Lada Type 1.5 Diabetes Diabetes Mellitus, Insulin-Dependent, Type 5
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Lymphopenia	Lymphocytopenia
Thyroiditis	Inflammation Of Thyroid Thyroiditis Nos
Achalasia	Cardiospasm Achalasia Of Cardia Esophageal Achalasia Hypertensive Lower Esophageal Sphincter Idiopathic Achalasia Achalasia Cardia Idiopathic Achalasia Of Esophagus Primary Achalasia Achalasia Of Esophagus Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter Aperistalsis Of The Oesophagus Achalasia Of Oesophagus Oesophageal Achalasia Achalasia Nos Cardia Spasm Cardia Achalasia Oesophageal Cardiospasm Oesophagus Achalasia Reflex Cardiospasm
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Chronic Urticaria	Urticaria Chronic Chronic Spontaneous Urticaria Chronic Ordinary Urticaria
Adrenal Cortical Hypofunction	Adrenal Cortical Insufficiency Corticoadrenal Insufficiency
Myasthenia Gravis	MG Acquired Myasthenia Autoimmune Myasthenia Gravis Erb-Goldflam Disease Mg - [Myasthenia Gravis] Myasthenia Gravis Nos Myasthenia
Diabetes Mellitus	Diabetes
Turner Syndrome	Monosomy X Gonadal Dysgenesis Turner Type Ullrich-Turner Syndrome Bonnevie-Ullrich Syndrome Karyotype 45, X Genital Dwarfism, Turner Type Gonadal Dysgenesis 45,X Turner'S Syndrome Gonadal Dysgenesis - Turner Monosomy X Syndrome Xo Syndrome Genital Dwarfism 45, X Syndrome Bonnevie-Ulrich Syndrome Chromosome X Monosomy X Schereshevkii Turner Syndrome Turner Varny Syndrome Ts 45,X Syndrome 45,X/46,Xx Syndrome Turners Syndrome Gonadal Dysgenesis, 45,X X0 Syndrome
Autoimmune Hepatitis	Aih Hepatitis, Autoimmune Autoimmune Chronic Active Hepatitis Autoimmune Hepatitis With Centrilobular Necrosis Autoimmune Chronic Hepatitis Hepatitis Autoimmune
Psoriasis
Type 1 Diabetes Mellitus 2	Diabetes Mellitus, Noninsulin-Dependent, 1 Diabetes Mellitus, Insulin-Dependent, 2 IDDM2 Insulin-Dependent Diabetes Mellitus 2 NIDDM1 Diabetes Mellitus, Noninsulin-Dependent 1 T1D2 Type 2 Diabetes Mellitus 1 T2D1 Noninsulin-Dependent Diabetes Mellitus 1 Diabetes Mellitus, Non-Insulin-Dependent, 1 Type 2 Diabetes Mellitus 1, Susceptibility To Diabetes Mellitus, Insulin-Dependent, Type 2 Diabetes Mellitus, Non-Insulin-Dependent
Autoimmune Disease Of Endocrine System
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Autoimmune Polyendocrine Syndrome, Type Ii	Schmidt Syndrome Autoimmune Polyendocrine Syndrome Type 2 APS2 Autoimmune Polyglandular Syndrome Type 2 Diabetes Mellitus, Addison Disease, Myxedema Polyglandular Autoimmune Syndrome, Type Ii Pga Ii Polyendocrine Autoimmune Syndrome, Type Ii Aps Ii Autoimmune Polyglandular Syndrome Type Ii Diabetes Mellitus, Addison'S Disease, Myxedema Multiple Endocrine Deficiency Syndrome, Type 2 Pga 2 Pga-Ii Polyglandular Autoimmune Syndrome, Type 2 Polyglandular Deficiency Syndrome Type 2 Schmidt'S Syndrome Autoimmune Polyendocrinopathy Type 2 Aps Type 2 Autoimmune Thyroid Disease And/Or Type 1 Diabetes-Addison Disease Syndrome Autoimmune Syndrome Type Ii Polyglandular Autoimmune Syndrome Type Ii, Polyglandular
Pernicious Anemia	Anemia, Pernicious Anemia Pernicious Pernicious Anaemia Addison'S Anaemia Biermer'S Anaemia Biermer'S Anemia Acquired Pernicious Anemia Addison-Biermer Anemia Addisonian Anemia Biermer Anemia Biermer'S Disease Juvenile Onset Pernicious Anemia Biermer Disease Biermer-Addison Disease
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Adrenal Cortex Disease	Adrenal Cortex Diseases
Juvenile Rheumatoid Arthritis	Juvenile Idiopathic Arthritis Juvenile Chronic Polyarthritis Monarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Arthritis Still'S Disease Systemic Juvenile Rheumatoid Arthritis Juvenile Chronic Arthritis Acute Juvenile Rheumatoid Arthritis Pauciarticular Onset Juvenile Chronic Arthritis Arthritis, Juvenile Rheumatoid Jia Jra Juvenile Ra Arthritis Juvenile Rheumatoid Stills Disease Juvenile Arthritis Acute Polyarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Rheumatoid Arthritis Rheumatoid Arthritis, Systemic Juvenile
Autoimmune Polyendocrine Syndrome	Autoimmune Polyendocrinopathy Autoimmune Polyglandular Failure Autoimmune Polyglandular Syndrome Polyendocrinopathies, Autoimmune Lloyd'S Syndrome Aps Polyendocrinopathies Autoimmune Polyendocrine Autoimmunity Syndrome Lloyd Syndrome Polyglandular Autoimmune Deficiency Progressive Pluriglandular Insufficiency Pluriglandular Autoimmune Atrophy Pluriglandular Autoimmune Syndrome Thyroid-Adrenocortical Insufficiency Syndrome
Autoimmune Disease Of Musculoskeletal System
Bone Inflammation Disease	Osteitis Bone Inflammatory Disease Inflammatory Disorder Of Bone
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139693	PTPN22-IN-1	Inhibitor	99.60%	Unkown
HY-156659	NC1	Inhibitor	98.73%	Unkown
HY-155848	LYP-IN-4	Inhibitor	98.60%	Unkown
HY-170564	PTPN22-IN-2	Inhibitor	/	Unkown
HY-183573	PTPRO-IN-1	Inhibitor	/	Unkown
HY-184931	PTPN22-IN-3		/	Unkown
HY-RS11424	PTPN22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17516	Ptpn22 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23973	Ptpn22 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PTPN22	MGD	MGI:107170
Macaca mulatta	PTPN22	VGNC	VGNC:76603
Felis catus	PTPN22	VGNC	VGNC:82499
Canis familiaris	PTPN22	VGNC	VGNC:45175
Rattus norvegicus	PTPN22	RGD	RGD:1307992
Bos taurus	PTPN22	VGNC	VGNC:33536
Others	PTPN22	NCBI