TAF1A - TATA-box binding protein associated factor, RNA polymerase I subunit A Gene

Also Known as SL1; RAFI48; TAFI48; MGC:17061

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9015

About TAF1A

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:222,554,105-222,589,933 (from NCBI)

This gene has 7 transcripts (splice variants), 201 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 2.3), lymph node (RPKM 1.9) and 24 other tissues.

Summary

This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]

TAF1A Products (3)

mRNA	Protein	Name
NM_001201536.1	NP_001188465.1	TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1
NM_005681.4	NP_005672.1	TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1
NM_139352.2	NP_647603.1	TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17318177	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase transcription factor SL1 complex	IDA IDA: Inferred from direct assay	11250903	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF1A Protein Structure

TAF1_subA

0
100
200
300
400
450 a.a.

Protein Preferred Names	Protein Names
TATA box-binding protein-associated factor RNA polymerase I subunit A	RNA polymerase I-specific TBP-associated factor 48 kDa

TAF1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TAF1A	Q15573	SET	Homo sapiens	Q01105	Pull Down	17318177
Intra	TAF1A	Q15573	SET	Homo sapiens	Q01105	Anti Tag CoIP	17318177
Intra	TAF1A	Q15573	TAF1B	Homo sapiens	Q53T94	Anti Tag CoIP	33961781
Intra	TAF1A	Q15573	TAF1B	Homo sapiens	Q53T94	Anti Tag CoIP	17318177
Intra	TAF1A	Q15573	TBP	Homo sapiens	P20226	Pull Down	17318177
Intra	TAF1A	Q15573	TBP	Homo sapiens	P20226	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Familial Isolated Dilated Cardiomyopathy	Familial Or Idiopathic Dilated Cardiomyopathy
Alopecia, Neurologic Defects, And Endocrinopathy Syndrome	Ane Syndrome ANES Alopecia-Progressive Neurological Defect-Endocrinopathy Syndrome Alopecia-Progressive Neurological Defect-Endocrinopathy Endocrine System Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14163	TAF1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TAF1A	VGNC	VGNC:35569
Felis catus	TAF1A	VGNC	VGNC:65927
Macaca mulatta	TAF1A	VGNC	VGNC:78087
Canis familiaris	TAF1A	VGNC	VGNC:47077
Mus musculus	TAF1A	MGD	MGI:109578
Rattus norvegicus	TAF1A	RGD	RGD:1305698
Others	TAF1A	NCBI