AIP - aryl hydrocarbon receptor interacting protein Gene

Also Known as ARA9; XAP2; PITA1; XAP-2; FKBP16; FKBP37; SMTPHN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9049

About AIP

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,483,026-67,491,103 (from NCBI)

This gene has 11 transcripts (splice variants), 204 orthologues, 1 paralogue and is associated with 8 phenotypes. Ubiquitous expression in lymph node (RPKM 29.1), spleen (RPKM 26.1) and 25 other tissues.

Summary

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing Enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

AIP Products (3)

mRNA	Protein	Name
NM_001302959.2	NP_001289888.1	AH receptor-interacting protein isoform 2
NM_001302960.2	NP_001289889.1	AH receptor-interacting protein isoform 3
NM_003977.4	NP_003968.3	AH receptor-interacting protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GAF domain binding	IDA IDA: Inferred from direct assay	17329248	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14557246	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	14557246	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein maturation by protein folding	IDA IDA: Inferred from direct assay	14557246	GOA
involved in protein targeting to mitochondrion	IDA IDA: Inferred from direct assay	14557246	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	17329248	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	17329248	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AIP Protein Structure

FKBP_C

0
100
200
300
330 a.a.

Protein Preferred Names	Protein Names
AH receptor-interacting protein	Ah receptor activated 9

AIP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AIP	O00170	PDE2A	Homo sapiens	O00408	Pull Down	17329248
Intra	AIP	O00170	PDE2A	Homo sapiens	O00408	Y2H	17329248
Intra	AIP	O00170	EGFR	Homo sapiens	P00533	Ub Reconstruction	31980649
Intra	AIP	O00170	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	28634279
Intra	AIP	O00170	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	19375531
Intra	AIP	O00170	HSP90AB1	Homo sapiens	P08238	Solution Sedimentation	21170051
Intra	AIP	O00170	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	25036637

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Pituitary Adenoma 1, Multiple Types	Pituitary Adenoma Predisposition PITA1 Isolated Familial Somatotropinoma Fis Ifs Somatotrophinoma, Familial Acromegaly Due To Pituitary Adenoma 1 Pagh1 Pituitary Adenoma 1 Somatotropinoma, Familial Isolated Somatotropic Adenoma Somatotropinoma Pituitary Gigantism Hypophyseal Gigantism Infantile And Juvenile Forms Of Acromegaly Acromegaly Due To Pituitary Adenoma Familial Isolated Pituitary Adenoma Familial Isolated Somatotropinomas Familial Somatotrophinoma Fipa Pituitary Adenoma, Growth Hormone-Secreting, 1 Gigantism Pituitary Pituitary Adenoma, Type 1, Multiple Types Gigantism Pituitary Adenoma, Familial Isolated Multiple Gastrointestinal Atresias
Growth Hormone Secreting Pituitary Adenoma	Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma Growth Hormone Producing Adenoma Of The Pituitary Growth Hormone Secreting Adenoma Of Pituitary
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Gastrointestinal Defects And Immunodeficiency Syndrome 1	Familial Intestinal Polyatresia Syndrome Fipa Gastrointestinal Defects And Immunodeficiency Syndrome Multiple Gastrointestinal Atresias Familial Isolated Pituitary Adenoma Intestinal Atresia, Multiple Multiple Intestinal Atresia GIDID1 Multiple Intestinal Atresia And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency Minat Gidid Meddra:10028210 Familial Isolated Pituitary Adenoma Syndrome Intestinal Atresia Multiple Combined Immunodeficiency-Enteropathy Spectrum Cid-Mia/Early-Onset Ibd Intestinal Atresia, Multiple And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency Mia Gastrointestinal Defect And Immunodeficiency Syndrome Pituitary Adenoma Predisposition Pituitary Adenoma, Familial Isolated
Acromegaly	Gigantism Growth Hormone Excess Pituitary Giant Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma
Prolactinoma	Prolactin-Producing Pituitary Gland Adenoma Prolactin-Secreting Pituitary Adenoma Forbes-Albright Syndrome Lactotroph Adenoma Prl-Secreting Pituitary Adenoma Prloma Pituitary Lactotrophic Adenoma Familial Prolactinoma Pituitary Adenoma, Prolactin-Secreting Prolactinoma Of Pituitary Gland PSPA
Silent Pituitary Adenoma	Non-Functioning Pituitary Gland Neoplasm
Null Pituitary Adenoma
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Hormone Producing Pituitary Cancer	Growth Hormone Producing Pituitary Tumor Pituitary Tumors, Hormone Producing Somatotropinoma Growth Hormone-Producing Pituitary Gland Neoplasm
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Pituitary Adenoma	Adenoma Of The Pituitary Gland Pituitary Adenomas Adenoma, Pituitary Pituitary Gland Adenoma Pituitary Neoplasms
Pituitary Apoplexy	Pituitary Tumor Apoplexy
Pituitary Cancer	Pituitary Carcinoma Malignant Pituitary Neoplasm Malignant Tumor Of Pituitary Gland Neoplasm Of Pituitary Gland Pituitary Gland Cancer Pituitary Gland Neoplasm Pituitary Neoplasm Carcinoma Of The Pituitary Gland Neoplasm Of The Pituitary Gland Pituitary Neoplasms Malignant Neoplasm Of Pituitary Gland
Lissencephaly, X-Linked, 2	X-Linked Lissencephaly With Abnormal Genitalia Hydranencephaly With Abnormal Genitalia Xlag Xlisg X-Linked Lissencephaly With Ambiguous Genitalia LISX2 Lissencephaly, X-Linked 2 X-Linked Lissencephaly 2 X-Linked Lissencephaly-Corpus Callosum Agenesis-Genital Anomalies Syndrome Xlag Syndrome Lissencephaly, X-Linked, With Ambiguous Genitalia Xlis2 X-Linked Lissencephaly - Agenesis Of The Corpus Callosum - Genital Anomalies X-Linked Lissencephaly-Agenesis Of The Corpus Callosum-Genital Anomalies Syndrome Xlag Syndrome Lissencephaly X-Linked With Ambiguous Genitalia Lissencephaly, X-Linked, Type 2 Chromosome Xq26.3 Duplication Syndrome
Carney Complex Variant	Carney Complex Carney Syndrome Carney Complex, Type 1 Lamb Syndrome Name Syndrome Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome Carney Complex - Trismus - Pseudocamptodactyly Syndrome Carney Complex, Type 2 Car Cnc1 Carney Myxoma-Endocrine Complex Myxoma - Spotty Pigmentation - Endocrine Overactivity Myxoma, Spotty Pigmentation, And Endocrine Overactivity Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome Carney Complex-Trismus-Pseudocamptodactyly Syndrome CACOV
Multiple Endocrine Neoplasia	Men Multiple Endocrine Adenomatosis Multiple Endocrine Neoplasia Syndrome Adenomatosis, Familial Endocrine Endocrine Neoplasia, Multiple Familial Endocrine Adenomatosis Mea Multiple Endocrine Neoplasms Multiple Endocrine Neoplasia Type 1
Functioning Pituitary Adenoma	Secretory Adenoma Of The Pituitary Gland Endocrine Active Pituitary Adenoma Secreting Pituitary Adenoma Pituitary Adenoma, Functioning
Hyperpituitarism
Pituitary Infarct	Pituitary Infarction
Multiple Endocrine Neoplasia, Type Iv	Multiple Endocrine Neoplasia Type 4 MEN4 Multiple Endocrine Neoplasia 4 Neoplasia, Endocrine, Multiple, Type Iv
Primary Hyperparathyroidism	Familial Primary Hyperparathyroidism Hyperparathyroidism, Primary Hyperparathyroidism Primary Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Benign Hypercalcemia Familial Hyperparathyroidism Parathyroid Enlargement
Pituitary Gland Disease	Pituitary Diseases Pituitary Dysfunction Pituitary Disease Pituitary Deficiency Pituitary Disorders
Tsh Producing Pituitary Tumor	Thyrotroph Adenoma Tsh Producing Pituitary Tumour Tsh Secreting Adenoma Of The Pituitary Tsh Secreting Tumor Of Pituitary Tsh Secreting Tumour Of Pituitary Tsh-Secreting Pituitary Adenoma Pituitary Thyrotrophic Adenoma Tsh-Oma Thyroid Stimulating Hormone-Secreting Pituitary Adenoma Thyroid Stimulating Hormone-Producing Pituitary Tumor
Acth-Secreting Pituitary Adenoma	Acth-Producing Pituitary Adenoma Corticotroph Adenoma Corticotropinoma Pituitary-Dependent Cushing'S Disease Adrenal Gland Hyperfunction Cushing Syndrome
Mccune-Albright Syndrome	Mass Syndrome Polyostotic Fibrous Dysplasia MAS Fibrous Dysplasia Of Bone Albright Syndrome Mass Phenotype Overlap Connective Tissue Disease Mccune Albright Syndrome Osteitis Fibrosa Disseminata OCTD Albright'S Disease Pfd Pofd Albright'S Syndrome Mccune-Albright Syndrome, Somatic, Mosaic Albright'S Disease Of Bone Albright'S Syndrome With Precocious Puberty Albright-Mccune-Sternberg Syndrome Albright-Sternberg Syndrome Fibrous Dysplasia With Pigmentary Skin Changes And Precocious Puberty Gonadotropin-Independent Female-Limited Sexual Precocity Fibrous Dysplasia Polyostotic Fibrous Dysplasia, Polyostotic
Endocrine Organ Benign Neoplasm
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-177554	KB05yne		99.97%	Unkown
HY-P10486	AIP-II	Inhibitor	98.04%	Unkown
HY-N17297	Leotiomycene C	Inhibitor	/	Unkown
HY-RS00499	AIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01269	AURKAIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02415	CDKN2AIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04442	EPM2AIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14904	TOR1AIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14905	TOR1AIP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14914	TP53AIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W249550	Co(AIP)(BPY)		/	Unkown
HY-RS17392	Aip Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23847	Aip Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	AIP	VGNC	VGNC:69759
Rattus norvegicus	AIP	RGD	RGD:628619
Felis catus	AIP	VGNC	VGNC:59703
Canis familiaris	AIP	VGNC	VGNC:37741
Mus musculus	AIP	MGD	MGI:109622
Bos taurus	AIP	VGNC	VGNC:25767
Others	AIP	NCBI