CDC27 - cell division cycle 27 Gene

Also Known as APC3; HNUC; NUC2; H-NUC; ANAPC3; CDC27Hs; D0S1430E; D17S978E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 996

About CDC27

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,117,703-47,189,295 (from NCBI)

This gene has 19 transcripts (splice variants), 205 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 20.3), testis (RPKM 11.6) and 25 other tissues.

Summary

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three Other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of Mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

CDC27 Products (9)

mRNA Protein Name
NM_001114091.4 NP_001107563.1 cell division cycle protein 27 homolog isoform 1
NM_001256.6 NP_001247.3 cell division cycle protein 27 homolog isoform 2
NM_001293089.3 NP_001280018.1 cell division cycle protein 27 homolog isoform 3
NM_001293091.3 NP_001280020.1 cell division cycle protein 27 homolog isoform 4
NM_001353035.2 NP_001339964.1 cell division cycle protein 27 homolog isoform 5
NM_001353047.2 NP_001339976.1 cell division cycle protein 27 homolog isoform 6
NM_001353049.2 NP_001339978.1 cell division cycle protein 27 homolog isoform 7
NM_001353050.2 NP_001339979.1 cell division cycle protein 27 homolog isoform 8
NM_001353051.2 NP_001339980.1 cell division cycle protein 27 homolog isoform 9

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10548110 GOA
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
21241890 GOA
Biological Process GO Annotation Evidence References Source
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: Inferred from direct assay
29033132 GOA
acts upstream of or within metaphase/anaphase transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
7736578 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
18485873 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
involved in protein branched polyubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
Cellular Component GO Annotation Evidence References Source
part of anaphase-promoting complex IDA
IDA: Inferred from direct assay
16364912 GOA
part of anaphase-promoting complex IPI
IPI: Inferred from physical interaction
27120157 GOA
located in centrosome IDA
IDA: Inferred from direct assay
7736578 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
7736578 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18445686 GOA
located in spindle IDA
IDA: Inferred from direct assay
18445686 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC27 Protein Structure

ANAPC3

ANAPC3: Anaphase-promoting complex, cyclosome, subunit 3 (17 - 93)

TPR_1

TPR_1: Tetratricopeptide repeat (118 - 146)

TPR_11

TPR_11: TPR repeat (600 - 666)

TPR_1

TPR_1: Tetratricopeptide repeat (671 - 702)

TPR_11

TPR_11: TPR repeat (703 - 768)

  • 0
  • 200
  • 400
  • 600
  • 824 a.a.
Protein Preferred Names Protein Names

cell division cycle protein 27 homolog

  • D0S1430E, D17S978E

CDC27 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDC27 P30260 COMT Homo sapiens P21964-2
Y2H Prey Pooling
25416956
Intra
CDC27 P30260 COMT Homo sapiens P21964-2
Y2H Array
25416956
Intra
CDC27 P30260 FOXO3 Homo sapiens O43524
Pull Down
25609649
Intra
CDC27 P30260 ANAPC4 Homo sapiens Q9UJX5
Anti Tag CoIP
35271311
Intra
CDC27 P30260 ANAPC4 Homo sapiens Q9UJX5
Anti Bait CoIP
26496610
Intra
CDC27 P30260 ANAPC4 Homo sapiens Q9UJX5
Anti Bait CoIP
21241890
Intra
CDC27 P30260 ANAPC4 Homo sapiens Q9UJX5
Anti Bait CoIP
20360068
Intra
CDC27 P30260 CDC20 Homo sapiens Q12834
Anti Tag CoIP
22014574
Intra
CDC27 P30260 CDC20 Homo sapiens Q12834
Anti Bait CoIP
17443180
Intra
CDC27 P30260 CDC20 Homo sapiens Q12834
Anti Bait CoIP
20212161
Intra
CDC27 P30260 CDC20 Homo sapiens Q12834
Anti Bait CoIP
21300909
Intra
CDC27 P30260 CDC20 Homo sapiens Q12834
Anti Tag CoIP
35271311
Intra
CDC27 P30260 CDC20 Homo sapiens Q12834
Anti Bait CoIP
22014574
Intra
CDC27 P30260 CDC20 Homo sapiens Q12834
Anti Bait CoIP
17443186
Intra
CDC27 P30260 CDC20 Homo sapiens Q12834
Anti Bait CoIP
20951947
Intra
CDC27 P30260 NEK2 Homo sapiens P51955
Anti Bait CoIP
16648845
Intra
CDC27 P30260 NEK2 Homo sapiens P51955
Anti Tag CoIP
35271311
Intra
CDC27 P30260 PTEN Homo sapiens P60484
Anti Bait CoIP
21241890
Intra
CDC27 P30260 PTEN Homo sapiens P60484
IF
21241890
Intra
CDC27 P30260 PTEN Homo sapiens P60484
Anti Tag CoIP
21241890
Intra
CDC27 P30260 FZR1 Homo sapiens Q9UM11
Anti Bait CoIP
21241890
Intra
CDC27 P30260 FZR1 Homo sapiens Q9UM11
Anti Bait CoIP
21186364
Intra
CDC27 P30260 FZR1 Homo sapiens Q9UM11
Anti Bait CoIP
18662541
Intra
CDC27 P30260 FZR1 Homo sapiens Q9UM11
Anti Bait CoIP
22014574
Intra
CDC27 P30260 CDH1 Homo sapiens P12830
Immunodepletion CoIP
20802534
Intra
CDC27 P30260 MAD2L2 Homo sapiens Q9UI95
Anti Bait CoIP
17719540
Intra
CDC27 P30260 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
20951947
Intra
CDC27 P30260 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
17443180
Intra
CDC27 P30260 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
20212161
Intra
CDC27 P30260 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
21300909
Intra
CDC27 P30260 MAD2L1 Homo sapiens Q13257
Anti Bait CoIP
17443186
Intra
CDC27 P30260 FBXO5 Homo sapiens Q9UKT4
Anti Bait CoIP
18662541
Cross: Cross-species interaction Intra: Intraspecies interaction

CDC27 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80073 Cdc27 Antibody (YA519) WB Human
HY-P85097 Cdc27 Antibody (YA4789) WB, IHC-P, ICC/IF, FC Human

Related Diseases

Diseases Alias
Glandular Tularemia
Pyomyositis

  • Tropical Pyomyositis

  • Myositis Tropicans

  • Myositis Purulenta Tropica

  • Pm

  • Suppurative Myositis

  • Purulent Myositis
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02295 CDC27 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16279 CDC27P9 Human Pre-designed siRNA Set A / Unkown
HY-RS16274 Human CDC27P10 Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CDC27 VGNC VGNC:60653
Mus musculus CDC27 MGD MGI:102685
Rattus norvegicus CDC27 RGD RGD:1304921
Bos taurus CDC27 VGNC VGNC:50040
Canis familiaris CDC27 VGNC VGNC:53202
Macaca mulatta CDC27 VGNC VGNC:70797
Others CDC27 NCBI