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Cat. No.: HY-P992541

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IBI3003

IBI3003 is a trispecific antibody targeting GPRC5D/BCMA/CD3. IBI3003 can redirect T cells to BCMA/GPRC5D-expressing multiple myeloma cells. IBI3003 is designed to overcome single tumor antigen escape caused by low expression of BCMA and GPRC5D. IBI3003 can be used in research on relapsed/refractory multiple myeloma.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IBI3003 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Species Reactivity
- In Vitro
- Target
- Conjugated
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Species Reactivity

Human

In Vitro

Anti-cancer

IBI3003 is a trispecific antibody targeting GPRC5D, BCMA, and CD3, designed to counteract single-antigen-mediated tumor escape; it exhibits potent cytotoxic activity against multiple myeloma with low BCMA and GPRC5D expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

RNA extraction experimental

Target

GPRC5D & BCMA & CD3

Conjugated

Unconjugated

Application

ELISA, FACS, Functional assay

Chemical Information

SMILES

[IBI3003]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Li J, et al. Initial Results of the first-in-human Phase 1 study of IBI3003, a novel trispecific antibody targeting GPRC5D, BCMA and CD3, in patients with relapsed or refractory multiple myeloma. Blood. 2025;146(Supplement 1):702.

[2]. van de Donk N W C J. Dual-antigen-targeting T-cell immunotherapies in MM: circumventing tumor heterogeneity and preventing antigen escape. Blood. 2026;147(19):2176-2193.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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