MCU-i11
Based on 3 publication(s) in Google Scholar
MCU-i11 is a negative regulator of the mitochondrial calcium uniporter (MCU) complex. MCU-i11 can reduce mitochondrial Ca2+ uptake. MCU-i11 impairs muscle cell growth. MCU-i11 can be used to study breast cancer, cervical cancer and neurological diseases.
For research use only. We do not sell to patients.
- Purity: 98.05%
- CAS No.: 902903-59-7
- Formula: C28H28N4O5S
- Molecular Weight:532.61
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MCU-i11
MoreAll Calcium Channel Isoforms
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Biological Activity
Mito_x0002_chondrial calcium uniporter (MCU)[1]
MCU-i11 (90 min) modulates mitochondrial Ca2+ uptake in intact HeLa cells, exerting a negative modulation[1].
MCU-i11 (10 μM) reduces mitochondrial Ca2+ uptake in mouse embryonic fibroblasts (MEFs), MDA-MB-231, and HEK293T cell lines[1].
MCU-i11 (10 μM) reduces WIN-induced increase in mitochondrial calcium levels in CB1-expressing astrocytes[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 902903-59-7
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Appearance Solid
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Molecular Weight 532.61
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Formula C28H28N4O5S
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Color Off-white to light brown
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SMILES
O=C(NC1=CC=C(OCC)C=C1)CN2C(N(CC3=CC=CC=C3)C(C4=C2SC5=C4CCN(C(C)=O)C5)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (3)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
MCUB Inhibits PRKN-Dependent Mitophagic Degradation of PD-L1 to Promote Immune Evasion in Bladder Cancer. [Abstract]2025 Nov 12:e14764. PMID: 41221601 -
Cell Prolif
Dissection of Mitochondrial Function via Chemical Perturbation and Single-Cell Profiling. [Abstract]2026 Apr 27:e70216. PMID: 42044679 -
Solvent & Solubility
DMSO : 87.5 mg/mL (164.29 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Di Marco G, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. [Content Brief]
[2]. Marmolejo-Garza A, et al. Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis. Cell Death Dis. 2023 Nov 25;14(11):772. [Content Brief]
[3]. Serrat R, et al. Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration. Cell Rep. 2021 Dec 21;37(12):110133. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8775 mL | 9.3877 mL | 18.7755 mL | 46.9387 mL |
| 5 mM | 0.3755 mL | 1.8775 mL | 3.7551 mL | 9.3877 mL | |
| 10 mM | 0.1878 mL | 0.9388 mL | 1.8775 mL | 4.6939 mL | |
| 15 mM | 0.1252 mL | 0.6258 mL | 1.2517 mL | 3.1292 mL | |
| 20 mM | 0.0939 mL | 0.4694 mL | 0.9388 mL | 2.3469 mL | |
| 25 mM | 0.0751 mL | 0.3755 mL | 0.7510 mL | 1.8775 mL | |
| 30 mM | 0.0626 mL | 0.3129 mL | 0.6258 mL | 1.5646 mL | |
| 40 mM | 0.0469 mL | 0.2347 mL | 0.4694 mL | 1.1735 mL | |
| 50 mM | 0.0376 mL | 0.1878 mL | 0.3755 mL | 0.9388 mL | |
| 60 mM | 0.0313 mL | 0.1565 mL | 0.3129 mL | 0.7823 mL | |
| 80 mM | 0.0235 mL | 0.1173 mL | 0.2347 mL | 0.5867 mL | |
| 100 mM | 0.0188 mL | 0.0939 mL | 0.1878 mL | 0.4694 mL |
MCU-i11 Related Classifications
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