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Cat. No.: HY-119340

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Mitoflaxone

(Synonyms: Flavoneacetic acid)

Mitoflaxone (flavoneacetic acid) is a synthetic flavonoid compound with vascular targeting properties. Mitoflaxone exerts anti-proliferative effects on endothelial cells through a superoxide-dependent mechanism, this effect leads to changes in the permeability of tumor blood vessels, thereby exerting anti-tumor effects^{[1]^{^{[2]^.}}}

For research use only. We do not sell to patients.

CAS No.: 87626-55-9
Formula: C₁₇H₁₂O₄
Molecular Weight:280.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Mitoflaxone Chemical Structure

CAS No.: 87626-55-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
2008	IC₅₀	421.3 μM Compound: FAA (Flavone -8-acetic acid)	Direct cytotoxicity against the selected tumor cell line 2008 was determined especially on ovarian adenocarcinoma derived cells Direct cytotoxicity against the selected tumor cell line 2008 was determined especially on ovarian adenocarcinoma derived cells	[PMID: 12904070]
A549	IC₅₀	341.5 μM Compound: 2, FAA	Cytotoxicity against human A549 cells after 24 hrs by MTT assay Cytotoxicity against human A549 cells after 24 hrs by MTT assay	[PMID: 24518295]
C13	IC₅₀	233.3 μM Compound: FAA (Flavone -8-acetic acid)	Direct cytotoxicity against the selected tumor cell line c13* was determined especially on ovarian adenocarcinoma derived cells Direct cytotoxicity against the selected tumor cell line c13* was determined especially on ovarian adenocarcinoma derived cells	[PMID: 12904070]
DLD-1	IC₅₀	>500 μg/mL Compound: 1 (FAA, NSC-347512 LM975)	In vitro concentration required to inhibit DLD1 cells In vitro concentration required to inhibit DLD1 cells	10.1016/0960-894X(94)85031-3
HCT-8	IC₅₀	245 μg/mL Compound: 1 (FAA, NSC-347512 LM975)	In vitro concentration required to inhibit HCT18 cells In vitro concentration required to inhibit HCT18 cells	10.1016/0960-894X(94)85031-3
HT-29	IC₅₀	2449.5 μM Compound: 2, FAA	Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay	[PMID: 24518295]
HT-29	IC₅₀	390 μg/mL Compound: 1 (FAA, NSC-347512 LM975)	In vitro concentration required to inhibit HT-29 cells In vitro concentration required to inhibit HT-29 cells	10.1016/0960-894X(94)85031-3
K562	IC₅₀	310 μg/mL Compound: 1 (FAA, NSC-347512 LM975)	In vitro concentration required to inhibit K562 cells In vitro concentration required to inhibit K562 cells	10.1016/0960-894X(94)85031-3
LoVo	IC₅₀	378.3 μM Compound: FAA (Flavone -8-acetic acid)	In vitro cytotoxicity against the selected tumor cell line LoVoR arising from human colon adenocarcinoma was determined In vitro cytotoxicity against the selected tumor cell line LoVoR arising from human colon adenocarcinoma was determined	[PMID: 12904070]
LoVo	IC₅₀	563.9 μM Compound: FAA (Flavone -8-acetic acid)	In vitro cytotoxicity against the selected tumor cell line LoVoS arising from human colon adenocarcinoma was determined In vitro cytotoxicity against the selected tumor cell line LoVoS arising from human colon adenocarcinoma was determined	[PMID: 12904070]
MAC15A	IC₅₀	150 μg/mL Compound: 1 (FAA, NSC-347512 LM975)	In vitro concentration required to inhibit MAC 15 A cells In vitro concentration required to inhibit MAC 15 A cells	10.1016/0960-894X(94)85031-3
MAC16	IC₅₀	180 μg/mL Compound: 1 (FAA, NSC-347512 LM975)	In vitro concentration required to inhibit MAC 16 cells In vitro concentration required to inhibit MAC 16 cells	10.1016/0960-894X(94)85031-3
MAC26	IC₅₀	208 μg/mL Compound: 1 (FAA, NSC-347512 LM975)	In vitro concentration required to inhibit MAC 26 cells In vitro concentration required to inhibit MAC 26 cells	10.1016/0960-894X(94)85031-3

Chemical Information

CAS No. 87626-55-9
Molecular Weight 280.27
Formula C₁₇H₁₂O₄
SMILES

O=C1C2=C(C(CC(O)=O)=CC=C2)OC(C3=CC=CC=C3)=C1
Synonyms

Flavoneacetic acid
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mitoflaxone. In subject area: Pharmacology, Toxicology and Pharmaceutical Science.

[2]. Yadav RP, et al. Purification and characterization of a regiospecific lipase from Aspergillus terreus. Biotechnology and applied biochemistry. 1998 Dec;28(3):243-9.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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