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Cat. No.: HY-P10422

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Multi-Leu peptide

(Synonyms: ML-peptide, Multi-Leucine (ML)-peptide)

Multi-Leu peptide (ML-peptide) is a potent inhibitor of PACE4 (K_i=22 nM). Multi-Leu peptide can competitively bind to the active site of PACE4 by simulating the substrate sequence of PACE4, thereby inhibiting its catalytic activity. Multi-Leu peptide can be used to study the specific mechanism of PACE4 in the development of prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 1413058-07-7
Formula: C₄₉H₉₄N₁₆O₉
Molecular Weight:1051.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Multi-Leu peptide Chemical Structure

CAS No.: 1413058-07-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	100 μM Compound: 1	Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay	[PMID: 30180568]
DU-145	IC₅₀	100 μM Compound: Ac-LLLLRVKR-NH2	Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23126600]
DU-145	IC₅₀	100 μM Compound: ML	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 24350995]
DU-145	IC₅₀	25 μM Compound: 1	Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay	[PMID: 30501188]
LNCaP	IC₅₀	180 μM Compound: 1	Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 30180568]
LNCaP	IC₅₀	180 μM Compound: Ac-LLLLRVKR-NH2	Cytotoxicity against human LNCAP cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human LNCAP cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 23126600]
LNCaP	IC₅₀	180 μM Compound: ML	Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 24350995]
LNCaP	IC₅₀	45 μM Compound: 1	Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 30501188]

Chemical Information

CAS No. 1413058-07-7
Molecular Weight 1051.37
Formula C₄₉H₉₄N₁₆O₉
Synonyms

ML-peptide, Multi-Leucine (ML)-peptide
Sequence

Ac-Leu-Leu-Leu-Leu-Arg-Val-Lys-Arg-NH2
Sequence Shortening

Ac-LLLLRVKR-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (257 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Łepek T, et al. Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations[J]. European journal of cell biology, 2017, 96(5): 476-485. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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