Syk
The Syk family of non-receptor tyrosine kinases comprises SYK and ZAP70, the key signal transducers of immune receptors. Both contain tandem N-terminal SH2 domains that bind the doubly phosphorylated ITAM motifs within immunoreceptor chains, unleashing their kinase domains and recruiting adapters such as LAT and SLP-76. ZAP70 is essentially restricted to T lymphocytes, where it transduces T-cell receptor signals for thymocyte development and antigen responses. SYK is broadly expressed, mediating B-cell receptor signaling, myeloid Fc receptor and C-type lectin responses, and platelet activation via the collagen receptor GPVI. Consequently, SYK inhibition with fostamatinib treats chronic immune thrombocytopenia, while ZAP70 expression serves as a prognostic marker in chronic lymphocytic leukemia.
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Syk Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
