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Vibecotamab

(Synonyms: XmAb14045)
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Based on 1 Customer Validation

Vibecotamab (XmAb14045) is a potent bispecific antibody targeting both CD123 and CD3. Vibecotamab targets T cell-mediated killing of CD123-expressing cells, regardless of T cell antigen specificity. Vibecotamab is a full length immunoglobulin molecule. Vibecotamab can be studied in research for diseases such as Myelodysplastic syndrome and acute myeloid leukemia. Recommend Isotype Control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3.

For research use only. We do not sell to patients.

  • Purity: 99.34%
  • CAS No.: 2138442-13-2
  • Molecular Weight:126.15 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Vibecotamab
  • Experimental Validation Results for Vibecotamab
  • Experimental Validation Results for Vibecotamab
  • Experimental Validation Results for Vibecotamab
  • Vibecotamab Chemical Structure
    Vibecotamab Chemical Structure
CAS No.: 2138442-13-2
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Vibecotamab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3

  • 1/16

    Immobilized Vibecotamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC50 for this effect is 0.48 ng/mL.

  • 1/16

    Immobilized Vibecotamab can bind Human IL-3R alpha/CD123 Protein (ECD, His Tag). The EC50 for this effect is 7.66 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Vibecotamab (HY-P99521). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

  • Vibecotamab Chemical Structure
    1/16
  • Vibecotamab
  • Immobilized Vibecotamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC50 for this effect is 0.48 ng/mL.
  • Immobilized Vibecotamab can bind Human IL-3R alpha/CD123 Protein (ECD, His Tag). The EC50 for this effect is 7.66 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Vibecotamab (HY-P99521). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.
  • half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3