ZN148
Based on 1 Customer Validation
ZN148 is a zinc-chelating synthetic metallo-β-lactamase (MBL) inhibitor which attenuates MBL-mediated carbapenem resistance. ZN148 can restore the in vitro clinical susceptibility to carbapenems in >98% of a large international collection of MBL-producing clinical Enterobacterales strains. ZN148 can be utilized in research on anti MBL-producing bacteria.
For research use only. We do not sell to patients.
- Purity : 98.58%
- CAS No.: 2190527-04-7
- Formula: C26H33N5O6
- Molecular Weight:511.57
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All Beta-lactamase Isoforms
More
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>100 μM
Compound: S29
|
Cytotoxicity against human HepG2 cells incubated for 24 hrs by AlamarBlue-based assay
Cytotoxicity against human HepG2 cells incubated for 24 hrs by AlamarBlue-based assay
|
[PMID: 37360393] |
Chemical Information
-
CAS No. 2190527-04-7
-
Appearance Solid
-
Molecular Weight 511.57
-
Formula C26H33N5O6
-
Color White to yellow
-
SMILES
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CN(C)C(C(C=N1)=CC=C1CN(CC2=CC=CC=N2)CC3=CC=CC=N3)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (195.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9548 mL | 9.7738 mL | 19.5477 mL | 48.8692 mL |
| 5 mM | 0.3910 mL | 1.9548 mL | 3.9095 mL | 9.7738 mL | |
| 10 mM | 0.1955 mL | 0.9774 mL | 1.9548 mL | 4.8869 mL | |
| 15 mM | 0.1303 mL | 0.6516 mL | 1.3032 mL | 3.2579 mL | |
| 20 mM | 0.0977 mL | 0.4887 mL | 0.9774 mL | 2.4435 mL | |
| 25 mM | 0.0782 mL | 0.3910 mL | 0.7819 mL | 1.9548 mL | |
| 30 mM | 0.0652 mL | 0.3258 mL | 0.6516 mL | 1.6290 mL | |
| 40 mM | 0.0489 mL | 0.2443 mL | 0.4887 mL | 1.2217 mL | |
| 50 mM | 0.0391 mL | 0.1955 mL | 0.3910 mL | 0.9774 mL | |
| 60 mM | 0.0326 mL | 0.1629 mL | 0.3258 mL | 0.8145 mL | |
| 80 mM | 0.0244 mL | 0.1222 mL | 0.2443 mL | 0.6109 mL | |
| 100 mM | 0.0195 mL | 0.0977 mL | 0.1955 mL | 0.4887 mL |
ZN148 Related Classifications
HY-176565 Related Classifications
Powered by Bioz