1. Metabolic Enzyme/Protease
  2. Dihydroorotate Dehydrogenase
  3. DHODH-IN-23


Cat. No.: HY-153112 Purity: 99.82%
COA Handling Instructions

DHODH-IN-23 (Compound A) is an orally active DHODH inhibitor that can be used for the research of cancer.

For research use only. We do not sell to patients.

DHODH-IN-23 Chemical Structure

DHODH-IN-23 Chemical Structure

CAS No. : 1346705-53-0

Size Price Stock Quantity
5 mg USD 100 In-stock
10 mg USD 160 In-stock
25 mg USD 350 In-stock
50 mg USD 550 In-stock
100 mg USD 950 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


DHODH-IN-23 (Compound A) is an orally active DHODH inhibitor that can be used for the research of cancer[1].

In Vitro

DHODH-IN-23 (Compound A; 72 h) inhibits acute myeloid leukemia cells proliferation[1].
DHODH-IN-23 (0.1-3 μM; 72 h) induces CDllb expression in THP-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: U937, HL-60, THP-1, KG-1 and MV411
Incubation Time: 72 h
Result: Inhibited cell growth with GI50s of 2.4, 2.5, 2.5, 3.5 and 7.6 μM against U937, THP-1, MV411 HL-60 and KG-1, respectively.


Cell Line: THP-1 cells
Concentration: 72 h
Incubation Time: 0.1, 1 and 3 μM
Result: Induced CDllb mRNA expression.
In Vivo

DHODH-IN-23 (Compound A; 30 mg/kg; oral; twice daily for 21 days) shows antitumor activity in MV411 mouse xenograft model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MV411 mouse xenograft model[1]
Dosage: 30 mg/kg
Administration: Oral administration, twice daily for 21 days
Result: Demonstrated significant anti-tumor activity both as a single agent and in combination with Cytarabine (HY-13605) at 20 mg/kg with tumor growth inhibitions of 37 and 73% respectively.
Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (282.88 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2631 mL 11.3153 mL 22.6306 mL
5 mM 0.4526 mL 2.2631 mL 4.5261 mL
10 mM 0.2263 mL 1.1315 mL 2.2631 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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