Dios-Arg diTFA
Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport.
For research use only. We do not sell to patients.
- CAS No.: 1807353-31-6
- Formula: C43H67F6N5O9
- Molecular Weight:912.01
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Dios-Arg shows high cytotoxicity (IC50 = 83.5 µg/mL in H1299; and IC50 = 74.1 µg/mL in HeLa), which may be due to the inhibition effect of diosgenin on HMG-CoA reductase, a rate-limiting enzyme involved in cholesterol biosynthesis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1807353-31-6
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Molecular Weight 912.01
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Formula C43H67F6N5O9
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SMILES
[H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](OC(CCCCCNC([C@@H](N)CCCNC(N)=N)=O)=O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H].O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ruilong Sheng, et al. Cationic Nanoparticles Assembled from Natural-Based Steroid Lipid for Improved Intracellular Transport of siRNA and pDNA. Nanomaterials (Basel). 2016 Apr 13;6(4):69. [Content Brief]
[2]. Ruilong Sheng, et al. Skeleton-Controlled pDNA Delivery of Renewable Steroid-Based Cationic Lipids, the Endocytosis Pathway Analysis and Intracellular Localization. Int J Mol Sci. 2018 Jan 26;19(2):369. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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