Diquafosol
Based on 5 publication(s) in Google Scholar
Diquafosol (INS365 free base) is a potent P2Y2 agonist. Diquafosol nhibits apoptosis and decreases ROS generation. Diquafosol has the potential for the research of dry eye.
For research use only. We do not sell to patients.
- CAS No.: 59985-21-6
- Formula: C18H26N4O23P4
- Molecular Weight:790.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Diquafosol
MoreAll P2Y Receptor Isoforms
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Biological Activity
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P2Y2 Receptor |
Diquafosol (3%; 24 h) inhibits apoptosis and decreases ROS generation in dry-conditioned hCECs[1].
Diquafosol (3%; 24 h) increases the protein expression of phospho-Erk1/2, phospho-Akt, and phospho-p90RSK in hCECs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human corneal epithelial cells (hCECs)
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Concentration:3% (diluted at 1:100)
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Incubation Time:24 h
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Result:Increased the protein expression of phospho-Erk1/2, phospho-Akt, and phospho-p90RSK.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6 weeks, 160-180 g Wistar female rats (dry eye model)[1]
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Dosage:ophthalmic solution 3%
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Administration:eyedrop, four times daily (8, 12 AM; 4, 8 PM) for 28 days
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Result:Increased the expression of phospho-Erk1/2, phospho-Akt, and phospho-p90RSK, inhibits apoptosis, decreased the IL-1β, TNF-α expression.
Chemical Information
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CAS No. 59985-21-6
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Molecular Weight 790.31
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Formula C18H26N4O23P4
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SMILES
O[C@H]1[C@@H](O)[C@H](N(C(N2)=O)C=CC2=O)O[C@@H]1COP(O)(OP(OP(OP(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C(NC(C=C4)=O)=O)O3)(O)=O)(O)=O)(O)=O)=O
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Synonyms
INS365 free base
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell Prolif
Establishment of human corneal epithelial organoids for ex vivo modelling dry eye disease. [Abstract]2024 Nov;57(11):e13704. PMID: 38961590 -
Commun Biol
2023 Aug 29;6(1):889. PMID: 37644178 -
Int J Mol Sci
2022 Jul 17;23(14):7870. PMID: 35887219 -
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Diquafosol Related Classifications
HY-B0606A Related Classifications
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