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Cat. No.: HY-169013

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DDO-3733

DDO-3733 is a TRP-independent Protein Phosphatase 5 (PP5) allosteric activator that promotes dephosphorylation of downstream substrates.

For research use only. We do not sell to patients.

CAS No.: 2923531-63-7
Formula: C₁₀H₆F₂N₂OS
Molecular Weight:240.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

DDO-3733 Chemical Structure

CAS No.: 2923531-63-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

DDO-3733 is a TRP-independent Protein Phosphatase 5 (PP5) allosteric activator that promotes dephosphorylation of downstream substrates^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	40.79 nM Compound: P5-22; DDO-3733	Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human HCT-116 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 78.49 nM) Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human HCT-116 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 78.49 nM)	[PMID: 39145509]
SW-620	IC₅₀	54.41 nM Compound: P5-22; DDO-3733	Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human SW620 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 122.3 nM) Enhancement of HSP90 inhibitor AT13387-induced antiproliferative activity against human SW620 cells assessed as HSP90 inhibitor AT13387 IC50 at 50 uM incubated for 72 hrs by CCK8 assay (Rvb = 122.3 nM)	[PMID: 39145509]

Chemical Information

CAS No. 2923531-63-7
Molecular Weight 240.23
Formula C₁₀H₆F₂N₂OS
SMILES

S=C(C1=CC2=C(F)C=C(F)C=C2OC1=N)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Q, et al. Allosteric Activation of Protein Phosphatase 5 with Small Molecules. J Med Chem. 2024 Sep 12;67(17):15080-15097. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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