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Cat. No.: HY-W716167

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Europine

Europine is a pyrrolizidine alkaloid present in the whole plant of Heliotropium crassifolium. Europine dose-dependently increases the micronucleus rate of metabolically active HepaRG cells, while reducing the relative cell viability.

For research use only. We do not sell to patients.

CAS No.: 570-19-4
Formula: C₁₆H₂₇NO₆
Molecular Weight:329.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Europine Chemical Structure

CAS No.: 570-19-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Europine (7.9‑60 μM; 24 h) induces micronucleus formation in metabolically active human hepatic HepaRG cells^[2].
Europine (1.95‑1000 μM; 24 h) dose-dependently increases the micronucleus rate (% MN) of metabolically active human hepatic HepaRG cells, while reducing the relative cell viability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

human hepatic HepaRG cells
Concentration:

1.95, 3.91, 7.81, 15.63, 31.25, 62.5, 125, 250, 500, 1000 μM
Incubation Time:

24 h
Result:

Reduced the relative cell viability.

Related Protocols :

Chemical Information

CAS No. 570-19-4
Molecular Weight 329.39
Formula C₁₆H₂₇NO₆
SMILES

CO[C@@H](C)[C@](C(C)(O)C)(O)C(OCC1=CCN2[C@@]1([H])[C@@H](O)CC2)=O
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Farsam H, et al. New pyrrolizidine alkaloids from Heliotropium crassifolium. Planta medica. 2000 May;66(4):389-91.

[2]. Allemang A, et al. Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells. Food and Chemical Toxicology, 2018, 121: 72‑81.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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