GCS-12–6
GCS-12-6 is a potent Th2-selective NKT cell agonist targeting the CD1d protein. GCS-12-6 mediates the rapid presentation of glycolipid/CD1d complexes on the surface of antigen-presenting cells. GCS-12-6 holds promise for research on autoimmune diseases (such as inflammatory bowel disease and multiple sclerosis).
For research use only. We do not sell to patients.
- Formula: C42H84N2O11S
- Molecular Weight:825.19
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
[2]|
CD1d |
IL-4 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:mouse splenocytes
-
Concentration:10, 100, 1000 nM
-
Incubation Time:72 h
-
Result:Did not exhibit apparent cytotoxicity at any of the tested concentrations, and the cell viability remained at a very high level.
In Vivo
GCS-12-6 (1 μg; i.p.; administered on days 2 and 4 of the experiment, twice in total; observation until day 8) significantly alleviates colonic inflammation, reduces the disease activity index, protects colonic length, and prevents body weight loss in the DSS (HY-116282C)-induced C57BL/6 mouse colitis model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 (female, 6-8 weeks old)[2]
-
Dosage:1 μg
-
Administration:i.p.; on days 2 and 4; 8 days
-
Result:Alleviated the body weight loss induced by DSS and significantly reduced the disease activity index (DAI) scores.
Dissection showed that colon shortening was significantly protected, and histopathological (H&E staining) results indicated that it could effectively alleviate the destruction of intestinal crypts and the infiltration of inflammatory cells.
Chemical Information
-
Molecular Weight 825.19
-
Formula C42H84N2O11S
-
SMILES
O[C@@H]([C@H](CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)NC(CCCCCCCCCCCNS(=O)(CCCCCC)=O)=O)[C@@H](CCCCCCCCCCCCCC)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GCS-12–6 Related Classifications
HY-175365 Related Classifications
Powered by Bioz