SNX5 - sorting nexin 5 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27131

About SNX5

Cytogenetic location: 20p11.23 Genomic coordinates (GRCh38): 20:17,941,600-17,968,794 (from NCBI)

This gene has 19 transcripts (splice variants), 227 orthologues and 15 paralogues. Ubiquitous expression in thyroid (RPKM 76.1), kidney (RPKM 52.7) and 24 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

SNX5 Products (3)

mRNA	Protein	Name
NM_001282454.2	NP_001269383.1	sorting nexin-5 isoform b
NM_014426.4	NP_055241.1	sorting nexin-5 isoform a
NM_152227.3	NP_689413.1	sorting nexin-5 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dynactin binding	IDA IDA: Inferred from direct assay	19619496	GOA
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	15561769	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19619496	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in pinocytosis	IDA IDA: Inferred from direct assay	18854019	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	25825816	GOA
involved in positive regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25825816	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	17148574	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic side of early endosome membrane	IDA IDA: Inferred from direct assay	15561769	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	15561769	GOA
located in macropinocytic cup	IDA IDA: Inferred from direct assay	18854019	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	25825816	GOA
part of retromer complex	IDA IDA: Inferred from direct assay	19619496	GOA
located in tubular endosome	IDA IDA: Inferred from direct assay	19619496	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX5 Protein Structure

PX

Vps5

0
100
200
300
404 a.a.

Protein Preferred Names	Protein Names
sorting nexin-5

SNX5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNX5	Q9Y5X3	SNX2	Homo sapiens	O60749	Anti Tag CoIP	35271311
Intra	SNX5	Q9Y5X3	SNX1	Homo sapiens	Q13596	Anti Tag CoIP	35271311
Intra	SNX5	Q9Y5X3	APPBP2	Homo sapiens	Q92624	Validated Y2H	25416956
Intra	SNX5	Q9Y5X3	APPBP2	Homo sapiens	Q92624	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

SNX5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81967	SNX5 Antibody (YA1712)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P81967A	SNX5 Antibody (YA1712)(PBS only)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13544	SNX5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SNX5	VGNC	VGNC:98451
Rattus norvegicus	SNX5	RGD	RGD:1310190
Canis familiaris	SNX5	VGNC	VGNC:46642
Mus musculus	SNX5	MGD	MGI:1916428
Felis catus	SNX5	VGNC	VGNC:65558
Others	SNX5	NCBI