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HPCA - hippocalcin Gene

Also Known as BDR2; DYT2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3208

About HPCA

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:32,885,996-32,894,646 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues, 14 paralogues and is associated with 2 phenotypes. Restricted expression toward brain (RPKM 57.7).

Summary

The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species. [provided by RefSeq, Jul 2008]

HPCA Products (1)

mRNA	Protein	Name
NM_002143.3	NP_002134.2	neuron-specific calcium-binding protein hippocalcin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IDA IDA: Inferred from direct assay	11964161	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	28398555	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	28398555	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to calcium ion	IMP IMP: Inferred from mutant phenotype	28398555	GOA
involved in regulation of voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	28398555	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28398555	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HPCA Protein Structure

EF-hand_1

EF-hand_7

0
100
193 a.a.

Protein Preferred Names	Protein Names
neuron-specific calcium-binding protein hippocalcin	calcium-binding protein BDR-2

HPCA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HPCA	P84074	CKMT1A	Homo sapiens	P12532	Y2H Array	32296183
Intra	HPCA	P84074	CKMT1A	Homo sapiens	P12532	Y2H Prey Pooling	32296183
Intra	HPCA	P84074	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	HPCA	P84074	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	HPCA	P84074	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	HPCA	P84074	VWC2	Homo sapiens	Q2TAL6	Y2H Prey Pooling	32296183
Intra	HPCA	P84074	VWC2	Homo sapiens	Q2TAL6	Validated Y2H	32296183
Intra	HPCA	P84074	VWC2	Homo sapiens	Q2TAL6	Y2H Array	32296183
Intra	HPCA	P84074	GATA5	Homo sapiens	Q9BWX5	Y2H Prey Pooling	32296183
Intra	HPCA	P84074	GATA5	Homo sapiens	Q9BWX5	Y2H Array	32296183
Intra	HPCA	P84074	GATA5	Homo sapiens	Q9BWX5	Validated Y2H	32296183
Intra	HPCA	P84074	MLLT10	Homo sapiens	P55197-2	Y2H Prey Pooling	32296183
Intra	HPCA	P84074	MLLT10	Homo sapiens	P55197-2	Y2H Array	32296183
Intra	HPCA	P84074	CREM	Homo sapiens	Q03060-25	Validated Y2H	32296183
Intra	HPCA	P84074	CREM	Homo sapiens	Q03060-25	Y2H Array	32296183
Intra	HPCA	P84074	CREM	Homo sapiens	Q03060-25	Y2H Prey Pooling	32296183
Intra	HPCA	P84074	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Prey Pooling	32296183
Intra	HPCA	P84074	C1QTNF2	Homo sapiens	Q9BXJ5	Validated Y2H	32296183
Intra	HPCA	P84074	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Array	32296183
Intra	HPCA	P84074	IL36RN	Homo sapiens	Q9UBH0	Validated Y2H	32296183
Intra	HPCA	P84074	MYDGF	Homo sapiens	Q969H8	Validated Y2H	32296183
Intra	HPCA	P84074	MYDGF	Homo sapiens	Q969H8	Y2H Array	32296183
Intra	HPCA	P84074	MYDGF	Homo sapiens	Q969H8	Y2H Prey Pooling	32296183
Intra	HPCA	P84074	DTX2	Homo sapiens	Q86UW9	Anti Tag CoIP	33961781
Intra	HPCA	P84074	DTX2	Homo sapiens	Q86UW9	Y2H Array	32296183
Intra	HPCA	P84074	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	32296183
Intra	HPCA	P84074	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
Intra	HPCA	P84074	UQCRB	Homo sapiens	P14927	Y2H Prey Pooling	32296183
Intra	HPCA	P84074	UQCRB	Homo sapiens	P14927	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

HPCA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811343	HPCA Antibody	WB, IHC-P	Human, Mouse
HY-P83007	Hippocalcin Antibody (YA2752)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Dystonia 2, Torsion, Autosomal Recessive	DYT2 Dystonia Musculorum Deformans 2 Torsion Dystonia 2 Dystonia Musculorum Deformans Type 2 Torsion Dystonia 2, Autosomal Recessive Type Primary Dystonia, Dyt2 Type Dystonia, Type 2, Torsion, Autosomal Recessive
Torsion Dystonia 2	Dystonia 2, Torsion, Autosomal Recessive
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Dystonia 25	DYT25 Dystonia-25 Dystonia, Type 25
Torsion Dystonia 4
Dystonia 6, Torsion	DYT6 Torsion Dystonia 6 Dystonia 6 Idiopathic Torsion Dystonia Of Mixed Type Primary Dystonia, Dyt6 Type Torsion Dystonia, Adult-Onset, Mixed Type Dyt-Thap1 Adolescent-Onset Dystonia Of Mixed Type Torsion Dystonia Adult Onset Mixed Type Dyt6 Dystonia Thap1 Dystonia Generalized Cervical And Upper-Limb-Onset Dystonia Adult-Onset Torsion Dystonia Mixed Type Autosomal Dominant Torsion Dystonia 6 Dystonia-6 Torsion Dystonia Type 6 Dystonia, Type 6, Torsion
Dystonia 27	DYT27 Primary Dystonia, Dyt27 Type Dystonia, Type 27
Spastic Monoplegia	Monoplegic Infantile Cerebral Palsy Spastic Monoplegic Cerebral Palsy Infantile Monoplegic Cerebral Palsy Cerebral Palsy Spastic Monoplegic Spastic Monoplegia Cerebral Palsy
Dystonia 24	DYT24 Cranio-Cervical Dystonia With Laryngeal And Upper-Limb Involvement Dystonia-24 Dystonia, Type 24
Dystonia 1, Torsion, Autosomal Dominant	Dystonia Musculorum Deformans 1 Dystonia Musculorum Deformans DYT1 Early-Onset Torsion Dystonia Eotd Dystonia-1, Torsion Torsion Dystonia 1 Autosomal Dominant Torsion Dystonia 1 Dystonia-1 Oppenheim'S Dystonia Oppenheim-Ziehen Disease Early Onset Torsion Dystonia Dystonia 3, Torsion, X-Linked
Segmental Dystonia
Multifocal Dystonia
Ascending Cholangitis
Spasmodic Dystonia	Laryngeal Dystonia
Dystonia 12	DYT12 Rdp Generalized Dystonia Dystonia-12 Rapid-Onset Dystonia-Parkinsonism Familial Dystonia Dystonia Musculorum Deformans Dystonic Disorders Idiopathic Familial Dystonia Dystonia-Parkinsonism, Rapid-Onset Fragments Of Torsion Dystonia Dyt-Atp1a3 Rapid-Onset Dystonia Parkinsonism Rodp Dystonia, Type 12 Dystonia 3, Torsion, X-Linked Idiopathic Non-Familial Dystonia Symptomatic Torsion Dystonia Dystonia Disorders
Leukodystrophy, Hypomyelinating, 6	Habc Hypomyelinating Leukodystrophy 6 HLD6 H-Abc Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum HLD Leukodystrophy, Hypomyelinating, Type 6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01791	CACNA1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06333	HPCA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17810	Hpca Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21232	Cacna1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24278	Hpca Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HPCA	RGD	RGD:620060
Mus musculus	HPCA	MGD	MGI:1336200
Macaca mulatta	HPCA	VGNC	VGNC:73509
Felis catus	HPCA	VGNC	VGNC:67635
Bos taurus	HPCA	VGNC	VGNC:29936
Canis familiaris	HPCA	VGNC	VGNC:52136
Others	HPCA	NCBI