SDC3 - syndecan 3 Gene

Also Known as SDCN; SYND3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9672

About SDC3

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:30,869,466-30,909,735 (from NCBI)

This gene has 4 transcripts (splice variants), 197 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in brain (RPKM 64.6), spleen (RPKM 56.5) and 21 other tissues.

Summary

The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin Cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. [provided by RefSeq, Oct 2009]

SDC3 Products (1)

mRNA Protein Name
NM_014654.4 NP_055469.3 syndecan-3 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18093920 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18093920 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDC3 Protein Structure

Syndecan

Syndecan: Syndecan domain (377 - 440)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 442 a.a.
Protein Preferred Names Protein Names

syndecan-3

  • N-syndecan

SDC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SDC3 O75056 SDC2 Homo sapiens P34741
Comigration in Gel
18093920
Intra
SDC3 O75056 SDC4 Homo sapiens P31431
Comigration in Gel
18093920
Intra
SDC3 O75056 RPS4Y1 Homo sapiens P22090
Anti Tag CoIP
33961781
Intra
SDC3 O75056 SDC3 Homo sapiens O75056
Comigration in Gel
18093920
Intra
SDC3 O75056 SDC3 Homo sapiens O75056
ToxCat
18093920
Intra
SDC3 O75056 MYZAP Homo sapiens P0CAP1
Anti Tag CoIP
33961781
Intra
SDC3 O75056 KRTAP5-9 Homo sapiens P26371
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SDC3 Proteins

Cat. No. Product Name Accession Purity
HY-P73624 Syndecan-3 Protein, Human (HEK293, His) ABM82826 (M1-K311) ≥ 85%, as determined by reducing SDS-PAGE.

SDC3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82369 Syndecan 3 Antibody (YA2114) WB Human, Mouse, Rat
HY-P82369A Syndecan 3 Antibody (YA2114)(PBS only) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Alcohol-Induced Mental Disorder

  • Psychoses, Alcoholic
Muscular Dystrophy

  • Muscular Dystrophies

  • Congenital Md

  • Congenital Muscular Dystrophy

  • Cmd

  • Mdc

  • Dystrophy, Muscular

  • Gower'S Muscular Dystrophy

  • Progressive Musclular Dystrophy

  • Pseudohypertrophic Atrophy

  • Pseudohypertrophic Muscle Paralysis

  • Pseudohypertrophic Muscular Atrophy

  • Pseudohypertrophic Muscular Dystrophy

  • Pseudohypertrophic Paralysis

  • Pseudomuscular Hypertrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12581 SDC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20818 Sdc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27332 Sdc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SDC3 MGD MGI:1349163
Macaca mulatta SDC3 VGNC VGNC:76999
Bos taurus SDC3 VGNC VGNC:34380
Canis familiaris SDC3 VGNC VGNC:45943
Felis catus SDC3 VGNC VGNC:64945
Rattus norvegicus SDC3 RGD RGD:621486
Others SDC3 NCBI