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Cat. No.: HY-118968

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(-)-SA2572

(-)-SA2572 is an orally active Ca²⁺ inward channel inhibitor. (-)-SA2572 inhibits the slow Ca²⁺ inward channel and the fast Na⁺ inward channel. (-)-SA2572 inhibits depolarization-induced contraction of gastrointestinal smooth muscle and vascular smooth muscle, prolongs atrioventricular nodal conduction time, and inhibits His bundle-ventricular conduction time. (-)-SA2572 reduces systolic blood pressure in spontaneously hypertensive rats. (-)-SA2572 can be used in the research of hypertension.

For research use only. We do not sell to patients.

CAS No.: 112946-90-4
Formula: C₃₂H₄₁ClN₂O₆S
Molecular Weight:617.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(-)-SA2572 Chemical Structure

CAS No.: 112946-90-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All Calcium Channel Isoforms :

In Vitro

(-)-SA2572 (compound (-)-1) potently inhibits Ca²⁺-induced contraction in isolated guinea pig caecal bands and potently inhibits Ca²⁺-induced contraction in isolated rabbit aortic strips, with higher potency than its (+)-enantiomer ^[1].
(-)-SA2572 prolongs the A-H interval and H-V interval conduction time in isolated rabbit hearts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(-)-SA2572 (compound (-)-1) (100 mg/kg; p.o.; single dose) produces a sustained hypotensive effect in conscious spontaneously hypertensive rats, with activity lasting up to 24 hours^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 112946-90-4
Molecular Weight 617.20
Formula C₃₂H₄₁ClN₂O₆S
SMILES

CC(N1[C@H](C2=C(C=CC(OC)=C2)OCCCCN(C)CCC3=CC(OC)=C(C(OC)=C3)OC)SC4=CC=CC=C41)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fujita M, et al. Synthesis and calcium antagonistic activity of (+)-(R)- and (-)-(S)-3-acetyl-2-[5-methoxy-2-[4-[N-methyl-N-(3,4,5- trimethoxyphenethyl)amino]butoxy]phenyl]benzothiazoline hydrochloride. Chemical & pharmaceutical bulletin. 1990 Apr;38(4):936-41.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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