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Cat. No.: HY-P3440A

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NOTA-WL12

NOTA-WL12 is a peptide-based imaging probe targeting PD-L1. NOTA-WL12 is a PD-L1 inhibitory peptide derivative and also a NOTA-conjugated WL12 precursor used for ⁶⁸Ga radiolabeling. The binding of NOTA-WL12 to human and mouse PD-L1 is evaluated by surface plasmon resonance. NOTA-WL12 is predicted by computational docking to interact with PD-L1.

For research use only. We do not sell to patients.

CAS No.: 2767203-39-2
Formula: C₁₁₁H₁₅₄N₂₆O₂₆S₂
Molecular Weight:2332.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NOTA-WL12 Chemical Structure

CAS No.: 2767203-39-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

NOTA-WL12 (1 mg/mL; 15 min) is radiolabeled to [¹⁸F]AlF-NOTA-WL12 with a yield of 29% and a radiochemical purity of 97.3%^[2].
NOTA-WL12 (50 µg; 15 min) is radiolabeled with ⁶⁸Ga at 90°C, yielding ⁶⁸Ga-WL12 with a radiochemical purity of > 99% as determined by HPLC^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2767203-39-2
Molecular Weight 2332.70
Formula C₁₁₁H₁₅₄N₂₆O₂₆S₂
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang Zhang, et al. PET Imaging of Peptide Probe Al[18F]F-NOTA-PCP1 for Monitoring the Engagement of PD-L1 Antibodies in Tumors. Mol. Pharmaceutics 4 March 2024; 21 (3): 1515-1525.

[2]. Ferro-Flores G, et al. Synthesis and Evaluation of [18F]AlF-NOTA-iPD-L1 as a Potential Theranostic Pair for [177Lu]Lu-DOTA-iPD-L1. Pharmaceutics. 2025 Jul 16;17(7):920. [Content Brief]

[3]. Li D, et al. Construction of an Iodine-Labeled CS1001 Antibody for Targeting PD-L1 Detection and Comparison with Low-Molecular-Peptide Micro-PET Imaging. Molecular pharmaceutics. 2022 Nov 07;19(11):4382-4389. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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