RX 336M
RX 336M is a dihydrocodeinone analogue. RX 336M induces behaviors consisting of consisting of behavioral activation, rapid forepaw movements, excessive grooming, and whole body "wet-dog" shakes (WDS) (rapid twisting of the head and trunk with the forepaws leaving the ground). RX 336M can be used for the study of neurological disease.
For research use only. We do not sell to patients.
- CAS No.: 6701-66-2
- Formula: C24H29NO3
- Molecular Weight:379.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague Dawley rats (weight ranges: 80-90 g, 120-140 g, 190-210 g, 280-300 g)[1]
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Dosage:1.5, 3, 6, 12 mg/kg
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Administration:i.p. for a single dose
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Result:Induced grooming behavior that primarily involved face washing and preening of the flanks with the mouth or forepaws, with very little hindpaw scratching.
Caused a sequential behavioral pattern in rats: shaking first, followed by face washing, then grooming of the flanks, and repetition of this sequence.
Led to a decrease in the correlation between the number of "wet-dog" shakes (WDS) and the percentage of maximum possible grooming episodes (%MGE).
Showed improved correlation between WDS and %MGE in rats weighing 190-210 g and 280-300 g.
Increased the number of WDS but decreased the correlation between WDS and grooming when the dose was doubled to 12 mg/kg in large rats.
Resulted in a decline in %MGE but an improvement in the correlation between shaking and grooming.
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Animal Model:Male and female Long-Evans rats of different ages (21 days, 30 days, 39 days, and 48 days old)[2]
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Dosage:6 mg/kg
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Administration:i.p. for a single dose
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Result:Induced more significant excessive grooming in younger rats than in older ones, with gender differences.
Caused age- and sex-related differences in the frequency of "wet-dog" shakes (WDS).
Had no significant effect on the activity levels (rearing and locomotion) of rats, while female rats generally had higher activity levels than males.
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Animal Model:39-day-old female Long-Evans rats received daily subcutaneous injections of testosterone benzoate (1 mg/kg/day) for 8 consecutive days starting from 32 days old[2]
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Dosage:6 mg/kg
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Administration:i.p. for a single dose
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Result:Enhanced the responses of female rats to excessive grooming and "wet-dog" shakes.
Had no significant behavioral effects in 39-day-old female rats pretreated with oil vehicle.
Chemical Information
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CAS No. 6701-66-2
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Molecular Weight 379.49
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Formula C24H29NO3
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SMILES
O=C1C2OC3=C(C=CC(CC4C5(C6C1)CCC(C)=C6C)=C3C25CCN4C)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lee EJ, et al. Discovery of a Novel Potent EGFR Inhibitor Against EGFR Activating Mutations and On-Target Resistance in NSCLC. Clin Cancer Res. 2024 Apr 15;30(8):1582-1594. [Content Brief]
[2]. Isaacson RL, et al. Age- and sex-related induction of excessive grooming and "wet-dog" shakes by the codeinone RX 336-M in the rat. Behav Neural Biol. 1987 May;47(3):250-61. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RX 336M Related Classifications
HY-122125 Related Classifications
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