Tobevibart
Based on 1 Customer Validation
Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096).
For research use only. We do not sell to patients.
- Purity: 99.39%
- CAS No.: 2645440-65-7
- Molecular Weight:143.234 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG1 lambda2
Virus
HBV
Tobevibart efficiently neutralizes HDV genotypes 1-3 and 5-8 in a dose-dependent manner with EC50 values ranging from 1.14 to 4.56 ng/mL. Tobevibart has pan-genotypic neutralization activity against different HBV/HDV combinations in vitro[1].
Tobevibart reduces infectious HDV levels in HBV/HDV co-infected primary human hepatocytes (PHH) in an additive manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 lambda2
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2645440-65-7
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Appearance Liquid
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Molecular Weight 143.234 kDa
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Color Colorless to light yellow
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SMILES
[Tobevibart]
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Synonyms
VIR-3434
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (255 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tobevibart Related Classifications
HY-P990015 Related Classifications
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