DMG-PEG2000-K237

DMG-PEG2000-K237 is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around the nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. K237 peptide: Targeting/functional ligand-the K237 peptide (sequence HTMYYHHYQHHL) binds to vascular endothelial growth factor receptor 2 (VEGFR-2/KDR), interfering with the specific binding of VEGF to the KDR receptor, thereby inhibiting tumor angiogenesis and tumor growth.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.