DMG-PEG2000-VIP

DMG-PEG2000-VIP is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing spatial separation between the lipid surface and the targeting ligand. 3. VIP peptide: Targeting/functional ligand-VIP peptide (vasoactive intestinal peptide) is an endogenous neuropeptide that specifically binds to VIP receptors (VPAC1 and VPAC2) highly expressed on the surface of various tumor cells (especially breast cancer), achieving tumor-targeted delivery and targeting breast cancer stem cells.

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