DOPE-PEG2000-THRPPMWSPVWP

DOPE-PEG2000-THRPPMWSPVWP: surface functionalization of liposomes and nanoparticles for mitochondria-targeted drug delivery, applicable in cancer therapy (targeting mitochondrial apoptosis pathways), mitochondrial disease treatment, and delivery of mitochondria-damaging agents.
Structural composition:
(1) DOPE; a fusogenic phospholipid with two oleoyl chains that anchors into lipid bilayers and promotes membrane fusion for cellular entry;
(2) PEG2000; a hydrophilic polymer that provides steric stabilization, reduces opsonization and immune clearance, and extends circulation half-life;
(3) THRPPMWSPVWP peptide; a mitochondria-penetrating peptide (MPP) that crosses cell membranes and selectively accumulates in mitochondria driven by the mitochondrial membrane potential, enabling direct delivery of therapeutic cargo (e.g., pro-apoptotic peptides, ROS-generating agents, or metabolic modulators) to mitochondria for modulating mitochondrial function and inducing apoptosis in target cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.