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Cat. No.: HY-187749A

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DPPE-PEG2000-PP1

Name: DPPE-PEG2000-PP1
Brand: MedChemExpress
SKU: HY-187749A
Availability: PreOrder

(Synonyms: DPPE-PEG2000-Mal-Cys-LSLERFLRCWSDAPA)

DPPE-PEG2000-PP1 (DPPE-PEG2000-Mal-Cys-LSLERFLRCWSDAPA) is a functionalized PEGylated phospholipid conjugate composed of three modular components: 1,2-dipalmitoyl-sn-glycerol-3-phosphate ethanolamine (DPPE) as a lipid anchoring group, a 2000 Da polyethylene glycol (PEG) spacer arm, and a PP1 (HY-P12012) peptide as a terminal targeting/functional ligand. DPPE-PEG2000-PP1 can be used in research on targeted drug delivery for atherosclerosis.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DPPE-PEG2000-PP1 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

DPPE-PEG2000-PP1 is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. PP1 peptide: Targeting/functional ligand-the PP1 peptide specifically binds to scavenger receptor type A type I (SR-AI), targeting inflammatory atherosclerotic plaques.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[DPPE-PEG2000-PP1]
Synonyms

DPPE-PEG2000-Mal-Cys-LSLERFLRCWSDAPA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Segers FM, et al. Design and validation of a specific scavenger receptor class AI binding peptide for targeting the inflammatory atherosclerotic plaque. Arteriosclerosis, thrombosis, and vascular biology. 2012 Apr;32(4):971-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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