DSPE-PEG3400-M2pep
DSPE-PEG3400-Mal-Cys-YEQDPWGVKWWY is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep, YEQDPWGVKWWY). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG3400-Mal-Cys-YEQDPWGVKWWY can be used for drug delivery.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DSPE-PEG-Mal-Cys-YEQDPWGVKWWY consists of three parts: a hydrophobic 1,2-distearate-sn-glycerol-3-phosphate ethanolamine (DSPE), a hydrophilic PEG chain, and a terminally modified M2pep targeting peptide (YEQDPWGVKWWY). This amphiphilic structure facilitates its embedding in the lipid bilayer while exposing the M2pep peptide on its outer surface, enabling the recognition of surface markers on M2 macrophages. It is noteworthy that the choice of PEG chain length (e.g., PEG2000) significantly affects blood circulation time and steric hindrance effects, requiring optimization based on specific experimental models.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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SMILES
[Mal-Cys-YEQDPWGVKWWY]C(CCOCCOC(NCCOP(OC[C@](COC(CCCCCCCCCCCCCCCCC)=O)([H])OC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O.[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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