E3 ligase Ligand 18
Based on 1 Customer Validation
E3 ligase Ligand 18 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 18 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
For research use only. We do not sell to patients.
- Purity: 99.22%
- CAS No.: 2241669-88-3
- Formula: C17H17ClN6O4S
- Molecular Weight:436.87
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cereblon |
Chemical Information
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CAS No. 2241669-88-3
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Appearance Solid
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Molecular Weight 436.87
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Formula C17H17ClN6O4S
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Color White to off-white
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SMILES
CC(N[C@H](C(O)=O)CSC1=NC(C(N=C(N2)N)=O)=C2N1CC3=CC=C(C=C3)Cl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 25 mg/mL (57.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2890 mL | 11.4451 mL | 22.8901 mL | 57.2253 mL |
| 5 mM | 0.4578 mL | 2.2890 mL | 4.5780 mL | 11.4451 mL | |
| 10 mM | 0.2289 mL | 1.1445 mL | 2.2890 mL | 5.7225 mL | |
| 15 mM | 0.1526 mL | 0.7630 mL | 1.5260 mL | 3.8150 mL | |
| 20 mM | 0.1145 mL | 0.5723 mL | 1.1445 mL | 2.8613 mL | |
| 25 mM | 0.0916 mL | 0.4578 mL | 0.9156 mL | 2.2890 mL | |
| 30 mM | 0.0763 mL | 0.3815 mL | 0.7630 mL | 1.9075 mL | |
| 40 mM | 0.0572 mL | 0.2861 mL | 0.5723 mL | 1.4306 mL | |
| 50 mM | 0.0458 mL | 0.2289 mL | 0.4578 mL | 1.1445 mL |
E3 ligase Ligand 18 Related Classifications
HY-129653 Related Classifications
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