1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. EMAC10101d

EMAC10101d 

Cat. No.: HY-138365
Handling Instructions

EMAC10101d is a potent and selective toward hCA II inhibitor, with a Ki of 8.1 nM.

For research use only. We do not sell to patients.

EMAC10101d Chemical Structure

EMAC10101d Chemical Structure

CAS No. : 2561476-24-0

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Description

EMAC10101d is a potent and selective toward hCA II inhibitor, with a Ki of 8.1 nM[1].

In Vitro

EMAC10101d exhibits Ki values of 9627.4 nM, 8.1 nM, 224.6 nM and 154.9 nM for hCA Ⅰ, hCA II, hCAⅨ and hCA Ⅻ, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

428.36

Formula

C₁₇H₁₅Cl₂N₃O₂S₂

CAS No.

2561476-24-0

SMILES

O=S(C1=CC=C(/N=C2SC=C(C3=CC=C(Cl)C=C3Cl)N\2CC)C=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (145.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3345 mL 11.6724 mL 23.3449 mL
5 mM 0.4669 mL 2.3345 mL 4.6690 mL
10 mM 0.2334 mL 1.1672 mL 2.3345 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.86 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

EMAC10101dCarbonic AnhydraseCarbonate dehydratasehCA II,Inhibitorinhibitorinhibit

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EMAC10101d
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HY-138365
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