ER-076349-d3
ER-076349-d3 (Eribulin intermediate-d3) is the deuterated-labeled ER-076349 (HY-42484). ER-076349 (Eribulin intermediate) is an inhibitor of tubulin polymerization, induces G2-M cell cycle arrest, and disrupts mitotic spindles. ER-076349 inhibits cancer cell growth, and inhibits tumor growth in several human tumor xenografts. ER-076349 is an analog of Halichondrin B.
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- 화학식: C40H55D3O12
- 분자량:733.90
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보관:Shipping with dry ice
-80°C, protect from light, stored under nitrogen
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
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Help & FAQs
Biological Activity
제품 설명
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- BrdU Incorporation Assay
- Somatic Cell Culture
- Patient-Derived Orthotopic Xenograft (PDOX)
- Protocol for Cell Cycle
- CCK-8/WST-8 Cell Proliferation Assay
- Cell Counting-Based Growth Curve Assay
- Cell Viability Determination by MTT Colorimetric Assay
- Flow cytometric DNA-content cell-cycle staining
- Protocol for Cell Counting and Cell Density Analysis
- Patient-Derived Xenograft (PDX)
- MTT Cell Proliferation Assay
- Subcutaneous Cell-Line-Derived Xenograft
- Orthotopic Cell-Line Xenograft
신청
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 253128-15-3
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Appearance Solid
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분자량 733.90
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화학식 C40H55D3O12
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SMILES
C[C@@H](C1=C)C[C@@H](O[C@@H]1C[C@@H]2O[C@H](C[C@H](O)CO)[C@H](OC([2H])([2H])[2H])[C@H]2CC3=O)CC[C@@H]4O[C@@H](CC[C@@]56C[C@]7([H])[C@H](O6)[C@H]8[C@@H](O7)[C@@H](O5)[C@@]9([H])O[C@@H](C3)CC[C@]9([H])O8)CC4=C
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Synonyms
Eribulin intermediate-d3
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선적
Shipping with dry ice.
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보관
-80°C, protect from light, stored under nitrogen
순도&문서
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ER-076349-d3 Related Classifications
HY-42484S Related Classifications
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