1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. ERα degrader 5

ERα degrader 5 (Compound 40) is a selective, orally bioavailable estrogen receptor (ER) degrader (SERD) with an EC50 of 1.1 nM against ERα. ERα degrader 5 shows antitumor effect in vivo.

For research use only. We do not sell to patients.

ERα degrader 5 Chemical Structure

ERα degrader 5 Chemical Structure

CAS No. : 2941268-96-6

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Description

ERα degrader 5 (Compound 40) is a selective, orally bioavailable estrogen receptor (ER) degrader (SERD) with an EC50 of 1.1 nM against ERα. ERα degrader 5 shows antitumor effect in vivo[1].

IC50 & Target

ERα

1.1 nM (EC50)

ERα

0.9 nM (IC50)

ERβ

2.3 nM (IC50)

In Vitro

ERα degrader 5 (Compound 40) shows antiproliferative activity with an IC50 of 1.0 nM against MCF-7[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

555.59

Formula

C29H25F4N3O2S

CAS No.
SMILES

CC(F)(C1=C(C2=C(C3=CC=C4NN=CC4=C3S2)OC5=CC=C(C=C5)OC6CN(C6)CCCF)C=CC(F)=C1)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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ERα degrader 5 Related Classifications

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Product Name:
ERα degrader 5
Cat. No.:
HY-146267
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