BPK-29
Based on 1 Customer Validation
BPK-29 is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. BPK-29 impairs the anchorage-independent growth of KEAP1-mutant cancer cells.
For research use only. We do not sell to patients.
- Purity: 99.4%
- CAS No.: 2143467-62-1
- Formula: C26H32ClN3O3
- Molecular Weight:470.00
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
BPK-29 substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2143467-62-1
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Appearance Solid
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Molecular Weight 470.00
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Formula C26H32ClN3O3
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Color White to off-white
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SMILES
O=C(N(C1CCN(C(C2=CC=C(N3CCOCC3)C=C2)=O)CCC1)CC4=CC=CC=C4)CCl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 52 mg/mL (110.64 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1277 mL | 10.6383 mL | 21.2766 mL | 53.1915 mL |
| 5 mM | 0.4255 mL | 2.1277 mL | 4.2553 mL | 10.6383 mL | |
| 10 mM | 0.2128 mL | 1.0638 mL | 2.1277 mL | 5.3191 mL | |
| 15 mM | 0.1418 mL | 0.7092 mL | 1.4184 mL | 3.5461 mL | |
| 20 mM | 0.1064 mL | 0.5319 mL | 1.0638 mL | 2.6596 mL | |
| 25 mM | 0.0851 mL | 0.4255 mL | 0.8511 mL | 2.1277 mL | |
| 30 mM | 0.0709 mL | 0.3546 mL | 0.7092 mL | 1.7730 mL | |
| 40 mM | 0.0532 mL | 0.2660 mL | 0.5319 mL | 1.3298 mL | |
| 50 mM | 0.0426 mL | 0.2128 mL | 0.4255 mL | 1.0638 mL | |
| 60 mM | 0.0355 mL | 0.1773 mL | 0.3546 mL | 0.8865 mL | |
| 80 mM | 0.0266 mL | 0.1330 mL | 0.2660 mL | 0.6649 mL | |
| 100 mM | 0.0213 mL | 0.1064 mL | 0.2128 mL | 0.5319 mL |
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