BQ0413
Based on 1 Customer Validation
BQ0413 exhibits good affinity to PSMA with a KD of 89 pM. BQ0413 exhibits good uptake and internalization property with an internalization rate of 44% in PC3-pip cell. BQ0413 can be used as tumor imaging agent when labeled with 99mTc.
For research use only. We do not sell to patients.
- Purity : 95.66%
- CAS No.: 3055338-52-5
- Formula: C69H96N12O24S
- Molecular Weight:1509.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 3055338-52-5
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Appearance Solid
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Molecular Weight 1509.63
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Formula C69H96N12O24S
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Color White to light yellow
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SMILES
OC([C@H](CCC(O)=O)NC(N[C@@H](CCCCNC([C@H](CC1=CC(C=CC=C2)=C2C=C1)NC([C@H](CC3=CC=C(O)C=C3)NC(CCCCCCCNC([C@H](CCCCNC(CNC(C(NC(C(NC(C(CCC(O)=O)NC(CS)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)=O)NC(C)=O)=O)=O)=O)=O)C(O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (66.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (1.66 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6624 mL | 3.3121 mL | 6.6241 mL | 16.5603 mL |
| 5 mM | 0.1325 mL | 0.6624 mL | 1.3248 mL | 3.3121 mL | |
| 10 mM | 0.0662 mL | 0.3312 mL | 0.6624 mL | 1.6560 mL | |
| 15 mM | 0.0442 mL | 0.2208 mL | 0.4416 mL | 1.1040 mL | |
| 20 mM | 0.0331 mL | 0.1656 mL | 0.3312 mL | 0.8280 mL | |
| 25 mM | 0.0265 mL | 0.1325 mL | 0.2650 mL | 0.6624 mL | |
| 30 mM | 0.0221 mL | 0.1104 mL | 0.2208 mL | 0.5520 mL | |
| 40 mM | 0.0166 mL | 0.0828 mL | 0.1656 mL | 0.4140 mL | |
| 50 mM | 0.0132 mL | 0.0662 mL | 0.1325 mL | 0.3312 mL | |
| 60 mM | 0.0110 mL | 0.0552 mL | 0.1104 mL | 0.2760 mL |
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