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Cat. No.: HY-P992336

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CRB0017

CRB0017 is a recombinant monoclonal antibody targeting ADAMTS5, with high affinity for the spacer domain of ADAMTS5 and strong antigen specificity. CRB0017 binds to the spacer domain of ADAMTS5 and reduces the proteolytic activity of this enzyme. CRB0017 delays articular cartilage degradation, alleviates the pathological severity of osteoarthritis, and decreases the osteoarthritis histopathological score. CRB0017 is applicable to the research of osteoarthritis.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CRB0017 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Species Reactivity

Human

IC₅₀ & Target^[1]

ADAMTS5

In Vivo

CRB0017 (1.2-12 mg per knee; intra-articular administration; 2 doses total, with a 6-week interval) significantly reduces all histopathological osteoarthritis (OA) scores in male STR/ort mice at the dose of 12 mg per knee^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

STR/ort (male, 5 months of age at study start)^[1]
Dosage:

1.2 mg per knee; 12 mg per knee
Administration:

intra-articular; 2 doses total 6 weeks apart
Result:

Reduced all OA histopathological scores (grade, stage, cell loss, GAG loss, OARSI score, Mankin’s score, total score) in a dose-dependent manner.
Decreased all parameters statistically significantly compared to vehicle at 12 mg per knee dose.
Showed a non-significant trend toward decreased scores for all parameters at 1.2 mg per knee dose.

Gene ID

11096 [NCBI]

Accession

Q9UNA0

Target

ADAMTS5

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

ELISA, FACS, Functional assay

Chemical Information

Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Chiusaroli R, et al. Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis. Osteoarthritis Cartilage. 2013;21(11):1807-1810. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References

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CRB0017

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Biological Activity

Chemical Information

Purity & Documentation

References

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CRB0017 Related Classifications

HY-P992336 Related Classifications