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Cat. No.: HY-182974

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DCAF1 binder 3

DCAF1 binder 3 is a DCAF1 binder and an E3 ligase ligand. DCAF1 binder 3 can be used to synthesize PROTAC SAMHD1 Degrader-1 (HY-182970).

For research use only. We do not sell to patients.

CAS No.: 3033533-52-4
Formula: C₁₉H₂₅FN₆
Molecular Weight:356.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DCAF1 binder 3 Chemical Structure

CAS No.: 3033533-52-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

DCAF1 binder 3 is a DCAF1 binder and an E3 ligase ligand. DCAF1 binder 3 can be used to synthesize PROTAC SAMHD1 Degrader-1 (HY-182970)^[1].

IC₅₀ & Target^[1]

DCAF1

All Ligands for E3 Ligase Isoforms :

In Vitro

DCAF1 binder 3 (Compound 19) DCAF1 binder 3 can be used to synthesize PROTAC SAMHD1 Degrader-1 (HY-182970)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3033533-52-4
Molecular Weight 356.44
Formula C₁₉H₂₅FN₆
SMILES

FC1=CC=CC(N2CCC[C@@H](NC3=NC=NC(N4CCNCC4)=C3)C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen X, et al. Discovery and Evaluation of a PROTAC Degrader Targeting SAMHD1 for the Treatment of Pulmonary Fibrosis. J Med Chem. Published online April 3, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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DCAF1 binder 3

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DCAF1 binder 3 Related Classifications

HY-182974 Related Classifications