CCR8 - C-C motif chemokine receptor 8 Gene

Also Known as CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1237

About CCR8

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:39,329,709-39,333,680 (from NCBI)

This gene has 2 transcripts (splice variants), 236 orthologues and 23 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the beta Chemokine Receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell Apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the Chemokine Receptor gene cluster region. [provided by RefSeq, Jul 2008]

CCR8 Products (1)

mRNA	Protein	Name
NM_005201.4	NP_005192.1	C-C chemokine receptor type 8

CCR8 Protein Structure

7tm_1

0
100
200
300
355 a.a.

Protein Preferred Names	Protein Names
C-C chemokine receptor type 8	CC chemokine receptor 8 CC chemokine receptor CHEMR1 CC-chemokine receptor chemr1 chemokine (C-C motif) receptor 8 chemokine (C-C) receptor 8 chemokine (C-C) receptor-like 2 chemokine receptor-like 1

Recombinant CCR8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77882	CCR8 Protein-VLP, Human (HEK293)	P51685 (M1-L355)	≥ 95%, as determined by HPLC.
HY-P700543	CCR8 Protein, Human (P. pastoris, His, Myc)	P51685 (M1-K35)	≥ 90%, as determined by reducing SDS-PAGE.

CCR8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810755	CCR8 Antibody (YA9998)	WB, ICC/IF	Human, Mouse, Rat
HY-P81628	CCR8 Antibody (YA1373)	FC, ELISA	Human

Related Diseases

Diseases	Alias
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Kaposi'S Sarcoma-Associated Herpesvirus Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Chromophobe Renal Cell Carcinoma	Chromophobe Adenocarcinoma Chromophobe Carcinoma Of Kidney Kidney Chromophobe Renal Cell Carcinoma, Chromophobe Cell Crcc Chrcc Chromophobe Renal Cell Adenocarcinoma Chromophobe Renal Carcinoma Chromophobe Carcinoma
Ileitis	Crohn'S Ileitis
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Molluscum Contagiosum	Water Warts Molluscum Verrucosum
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Human Immunodeficiency Virus Infectious Disease	Hiv Infections

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990914	Denikitug		99.00%	Phase 2
HY-P991481	S-531011	Inhibitor	98.38%	Phase 2
HY-P991061	Tagmokitug	Inhibitor	99.9%	Phase 1
HY-P991942	Lanerkitug	Inhibitor	97.00%	Phase 1
HY-P991944	ZL-1218	Inhibitor	/	Phase 1
HY-P991135	Enzelkitug	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119217	AZ084	Antagonist	99.70%	Unkown
HY-122219	R243	Antagonist	98.09%	Unkown
HY-124416	ML604086	Inhibitor	99.78%	Unkown
HY-121885	LMD-009	Agonist	99.35%	Unkown
HY-101038A	ZK756326 dihydrochloride	Agonist	99.87%	Unkown
HY-144197	CCR8 antagonist 1	Antagonist	99.50%	Unkown
HY-176799	LMD-584	Agonist	/	Unkown
HY-176800	LMD-902	Agonist	/	Unkown
HY-153669	SB-649701	Antagonist	/	Unkown
HY-184668	CCR8 agonist 2	Agonist	/	Unkown
HY-160647	CCR8 antagonist 3	Antagonist	/	Unkown

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991942A	Lanerkitug (FUT8-KO)	Inhibitor	98.85%	Unkown
HY-P991481A	S-531011 (FUT8-KO)	Inhibitor	99.10%	Unkown
HY-P991944A	ZL-1218 (FUT8-KO)	Inhibitor	/	Unkown
HY-P992334	CM369	Inhibitor	/	Unkown
HY-P991135A	Enzelkitug (FUT8-KO)	Inhibitor	/	Unkown
HY-P992365	HFB101110	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CCR8	VGNC	VGNC:26988
Felis catus	CCR8	VGNC	VGNC:60574
Mus musculus	CCR8	MGD	MGI:1201402
Rattus norvegicus	CCR8	RGD	RGD:1304893
Macaca mulatta	CCR8	VGNC	VGNC:84216
Canis familiaris	CCR8	VGNC	VGNC:38916
Others	CCR8	NCBI