ITK antagonist
Based on 1 Customer Validation
ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM.
For research use only. We do not sell to patients.
- CAS No.: 1149753-56-9
- Formula: C26H34N6O2S
- Molecular Weight:494.65
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| T-cell | IC50 |
20 nM
Compound: 10n
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Inhibition of anti-CD3 and anti-CD28 monoclonal antibody-stimulated IL2 secretion in human CD4+ T cells
Inhibition of anti-CD3 and anti-CD28 monoclonal antibody-stimulated IL2 secretion in human CD4+ T cells
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[PMID: 19246196] |
Chemical Information
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CAS No. 1149753-56-9
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Appearance Solid
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Molecular Weight 494.65
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Formula C26H34N6O2S
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Color Off-white to light yellow
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SMILES
CC(C)(O)CN1C2=CC=C(CN[C@@H](C)C(C)(C)C)C=C2N=C1NC(C3=CC=C(C4=CNN=C4)S3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (265 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ITK antagonist Related Classifications
HY-13232 Related Classifications
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