MRL-650
MRL-650 (CB1 inverse agonist 1), a chemical probe, is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects.
For research use only. We do not sell to patients.
- CAS No.: 852315-00-5
- Formula: C25H18Cl3N3O3
- Molecular Weight:514.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CB1 7.5 nM (IC50) |
CB2 4100 nM (IC50) |
The pharmacokinetic profile of CB1 inverse agonist 1 is evaluated in Sprague-Dawley rats, C57BL/6 mice, beagles, and rhesus macaques with t1/2 of >8, >8, >24, and 22 h, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat[1]
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Dosage:0.3, 1, or 3 mg/kg
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Administration:PO
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Result:Inhibited feeding in a dose-dependent manner. 3 mg/kg decreased cumulative food intake from 2 h post-dosing. Decreased overnight body weight gain compared to vehicle treatment at all dosing levels.
Chemical Information
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CAS No. 852315-00-5
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Molecular Weight 514.79
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Formula C25H18Cl3N3O3
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SMILES
CC(NC1=C(C(C)=O)C(N(C)C2=NC(C3=CC=C(Cl)C=C3Cl)=C(C4=CC=C(Cl)C=C4)C=C12)=O)=O
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Synonyms
CB1 inverse agonist 1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MRL-650 Related Classifications
HY-135280 Related Classifications
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