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Cat. No.: HY-149712

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Spermatinamine

Spermatinamine is a novel alkaloid with a bromotyrosyl-spermine-bromotyrosyl sequence, and a natural ICMT inhibitor. Spermatinamine can be isolated from the Australian sponge Pseudoceratina.

For research use only. We do not sell to patients.

CAS No.: 1001438-81-8
Formula: C₃₂H₄₄Br₄N₆O₆
Molecular Weight:928.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Spermatinamine Chemical Structure

CAS No.: 1001438-81-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Spermatinamine is a novel alkaloid with a bromotyrosyl-spermine-bromotyrosyl sequence, and a natural ICMT inhibitor. Spermatinamine can be isolated from the Australian sponge Pseudoceratina^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	1.6 μM Compound: 1	Cytotoxicity against human DU145 cells assessed as viable cells after 24 hrs by Solid plate-based spot culture growth inhibition assay Cytotoxicity against human DU145 cells assessed as viable cells after 24 hrs by Solid plate-based spot culture growth inhibition assay	[PMID: 26874403]
MCF7	IC₅₀	1.6 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as viable cells after 24 hrs by Solid plate-based spot culture growth inhibition assay Cytotoxicity against human MCF7 cells assessed as viable cells after 24 hrs by Solid plate-based spot culture growth inhibition assay	[PMID: 26874403]

Chemical Information

CAS No. 1001438-81-8
Molecular Weight 928.34
Formula C₃₂H₄₄Br₄N₆O₆
SMILES

BrC1=C(OC)C(Br)=CC(C/C(C(NCCCN(C)CCCCN(C)CCCNC(/C(CC2=CC(Br)=C(OC)C(Br)=C2)=N/O)=O)=O)=N\O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Buchanan MS et al. Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6860-3. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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