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Cat. No.: HY-128592

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TAB29

TAB29 is a potent inhibitor of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) with an IC₅₀ of 874 nM, possesses therapeutic potential for human cancers.

For research use only. We do not sell to patients.

CAS No.: 2361144-71-8
Formula: C₂₈H₂₂O₃
Molecular Weight:406.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

TAB29 Chemical Structure

CAS No.: 2361144-71-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

TAB29 is a potent inhibitor of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) with an IC₅₀ of 874 nM, possesses therapeutic potential for human cancers^[1].

IC₅₀ & Target

IC50：874 nM (Pin1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
SK-HEP1	IC₅₀	1.14 μM Compound: TAB29	Cytotoxicity against human SKHEP1 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human SKHEP1 cells assessed as reduction in cell viability by MTT assay	[PMID: 31027708]
SNU-423	IC₅₀	2.732 μM Compound: TAB29	Cytotoxicity against human SNU423 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human SNU423 cells assessed as reduction in cell viability by MTT assay	[PMID: 31027708]

Chemical Information

CAS No. 2361144-71-8
Molecular Weight 406.47
Formula C₂₈H₂₂O₃
SMILES

C1(OCC2=CC=CC=C2)=CC(OCC3=CC=CC=C3)=C4C(OC=C4C5=CC=CC=C5)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fan X, et al. Discovery of 4,6-bis(benzyloxy)-3-phenylbenzofuran as a novel Pin1 inhibitor to suppress hepatocellular carcinoma via upregulating microRNA biogenesis. Bioorg Med Chem. 2019 Jun 1;27(11):2235-2244. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

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100 mg

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