2-Hydroxy-3-methoxychalcone
2-Hydroxy-3-methoxychalcone is a methoxy-derivative of 2'-Hydroxychalcone with an anticancer activity.
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- No. CAS: 7146-86-3
- Fòrmula: C16H14O3
- Peso molecular:254.28
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Neutrophil | IC50 |
3 μM
Compound: 10
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Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
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[PMID: 33006891] |
| Neutrophil | IC50 |
5.7 μM
Compound: 10
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Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
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[PMID: 33006891] |
| THP-1 | CC50 |
>25 μM
Compound: 1
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Cytotoxicity against human THP1 cells by MTT assay
Cytotoxicity against human THP1 cells by MTT assay
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[PMID: 28064141] |
In Vitro
2-Hydroxy-3-methoxychalcone (TJ3) (10 µM and 25 µM) significantly reduces the concentration of MIF secreted by SW480 cells which correlates with downregulations of ICAM-1. 2-Hydroxy-3-methoxychalcone (25 µM) increases the concentration of IL-8 in SW480 and SW620 cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 7146-86-3
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Peso molecular 254.28
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Fòrmula C16H14O3
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SMILES
O=C(C1=CC=CC=C1O)C=CC2=CC=CC(OC)=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Hydroxy-3-methoxychalcone Related Classifications
HY-W411442 Related Classifications
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