MM-589
MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM.
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- No. CAS: 2097887-20-0
- Fòrmula: C28H44N8O5
- Peso molecular:572.70
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
IC50: 0.90 nM (WDR5), 12.7 nM (HMT)[1]
Ki: <1 nM (WDR5)[1]
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Cell Line
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Type | Value | Description | References |
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| MV4-11 | IC50 |
250 nM
Compound: MM-589
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Anti-proliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition treated for 4 days by WST-8 cell proliferation assay
Anti-proliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition treated for 4 days by WST-8 cell proliferation assay
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[PMID: 35436124] |
MM-589 (0.01-10 μM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV4-11 and MOLM-13 cells
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Concentration:0.01, 0.1, 1, 10 μM
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Incubation Time:4 days or 7 days
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Result:Potently inhibited MV4-11 and MOLM-13 cell growth with IC50s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC50 of 8.6 μM.
Chemical Information
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No. CAS 2097887-20-0
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Peso molecular 572.70
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Fòrmula C28H44N8O5
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SMILES
O=C(NCC[C@](NC(C(C)C)=O)(C)C1=O)[C@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N1)=O)CC)=O)C2=CC=CC=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (174.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
Referencias
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7461 mL | 8.7306 mL | 17.4611 mL | 43.6529 mL |
| 5 mM | 0.3492 mL | 1.7461 mL | 3.4922 mL | 8.7306 mL | |
| 10 mM | 0.1746 mL | 0.8731 mL | 1.7461 mL | 4.3653 mL | |
| 15 mM | 0.1164 mL | 0.5820 mL | 1.1641 mL | 2.9102 mL | |
| 20 mM | 0.0873 mL | 0.4365 mL | 0.8731 mL | 2.1826 mL | |
| 25 mM | 0.0698 mL | 0.3492 mL | 0.6984 mL | 1.7461 mL | |
| 30 mM | 0.0582 mL | 0.2910 mL | 0.5820 mL | 1.4551 mL | |
| 40 mM | 0.0437 mL | 0.2183 mL | 0.4365 mL | 1.0913 mL | |
| 50 mM | 0.0349 mL | 0.1746 mL | 0.3492 mL | 0.8731 mL | |
| 60 mM | 0.0291 mL | 0.1455 mL | 0.2910 mL | 0.7275 mL | |
| 80 mM | 0.0218 mL | 0.1091 mL | 0.2183 mL | 0.5457 mL | |
| 100 mM | 0.0175 mL | 0.0873 mL | 0.1746 mL | 0.4365 mL |
MM-589 Related Classifications
HY-100869 Related Classifications
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