AAF-CMK
AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor, shows anti-tumor activity and induces apoptosis. AAF-CMK can be used in leukemia research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 102129-66-8
- Fòrmula: C16H22ClN3O3
- Peso molecular:339.82
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
AAF-CMK (0-20 μM; 24 h) shows potentiated antitumor effects of U937 leukemia cells in combination with TRAIL or TNF[1].
AAF-CMK (20 μM; 24 h) increases TNF- and TRAIL-induced U937 cell apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U937 human promonocytic leukemia cells
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Concentration:0-20 μM
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Incubation Time:24 h
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Result:Resulted in the potentiation of growth inhibitory cytostatic effects of TRAIL as well as TNF.
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Cell Line:U937 human promonocytic leukemia cells
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Concentration:20 μM
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Incubation Time:24 h
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Result:Increased the percentage of apoptotic cells to 55.8% in combination with TRAIL.
Increased number of cells with characteristic apoptotic morphology in groups treated with AAF-CMK and both TRAIL or TNF compared to each group treated alone.
Chemical Information
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No. CAS 102129-66-8
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Peso molecular 339.82
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Fòrmula C16H22ClN3O3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AAF-CMK Related Classifications
HY-129407A Related Classifications
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