CN128 hydrochloride
Based on 1 Customer Validation
CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.15%
- No. CAS: 1335282-05-7
- Fòrmula: C15H18ClNO3
- Peso molecular:295.76
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Actividad biológica
The iron removal efficacies of CN128 displays a dose-dependent behavior[1].
CN128 hydrochloride lacks genetic toxicity[1].
CN128 hydrochloride (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg[1].
CN128 hydrochloride is well-tolerated, with no mortality being observed at the higher dose levels in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male SD rats (300 g)[1]
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Dosage:450 μmol/kg
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Administration:Oral gavage, 1 hour after 59Fe-ferritin injection
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Result:Exhibited good iron scavenging activity.
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Animal Model:Sprague-Dawley rats (200~250 g)[1]
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Dosage:75 μmol/kg (Pharmacokinetic Analysis)
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Administration:Oral administration
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Result:AUC values= 16.38 mg/L•h, Cmax=8.671 mg/L.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 1335282-05-7
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Appearance Solid
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Peso molecular 295.76
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Fòrmula C15H18ClNO3
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Color Off-white to light brown
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SMILES
O=C1C(O)=C(C)N([C@@H](CO)CC2=CC=CC=C2)C=C1.[H]Cl
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Synonyms
CN328
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
H2O : 100 mg/mL (338.11 mM; Need ultrasonic)
DMSO : 28.57 mg/mL (96.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.86 mg/mL (9.67 mM); Clear solution
This protocol yields a clear solution of ≥ 2.86 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (28.6 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.86 mg/mL (9.67 mM); Clear solution
This protocol yields a clear solution of ≥ 2.86 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (28.6 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.3811 mL | 16.9056 mL | 33.8112 mL | 84.5280 mL |
| 5 mM | 0.6762 mL | 3.3811 mL | 6.7622 mL | 16.9056 mL | |
| 10 mM | 0.3381 mL | 1.6906 mL | 3.3811 mL | 8.4528 mL | |
| 15 mM | 0.2254 mL | 1.1270 mL | 2.2541 mL | 5.6352 mL | |
| 20 mM | 0.1691 mL | 0.8453 mL | 1.6906 mL | 4.2264 mL | |
| 25 mM | 0.1352 mL | 0.6762 mL | 1.3524 mL | 3.3811 mL | |
| 30 mM | 0.1127 mL | 0.5635 mL | 1.1270 mL | 2.8176 mL | |
| 40 mM | 0.0845 mL | 0.4226 mL | 0.8453 mL | 2.1132 mL | |
| 50 mM | 0.0676 mL | 0.3381 mL | 0.6762 mL | 1.6906 mL | |
| 60 mM | 0.0564 mL | 0.2818 mL | 0.5635 mL | 1.4088 mL | |
| 80 mM | 0.0423 mL | 0.2113 mL | 0.4226 mL | 1.0566 mL | |
| H2O | 100 mM | 0.0338 mL | 0.1691 mL | 0.3381 mL | 0.8453 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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