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Referencia número: HY-W1126955

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Enlicitide (decanoate)

(Synonyms: MK-0616 (decanoate))

Enlicitide (MK-0616) decanoate is an orally active macrocyclic peptide PCSK9 inhibitor. Enlicitide decanoate binds to PCSK9, blocks its interaction with low-density lipoprotein receptor (LDLR), and enhances hepatic clearance of LDL-C. Enlicitide decanoate reduces atherogenic lipoproteins, including non-HDL cholesterol, apolipoprotein B, and lipoprotein (a). Enlicitide decanoate is applicable to research related to hypercholesterolemia, heterozygous familial hypercholesterolemia, and atherosclerotic cardiovascular disease.

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No. CAS: 2861205-06-1
Fòrmula: C₉₂H₁₂₉FN₁₄O₁₇
Peso molecular:1722.09

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Síntesis personalizada de péptidos

Enlicitide (decanoate) Chemical Structure

No. CAS: 2861205-06-1

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Actividad biológica

Descripciòn

In Vitro

Enlicitide decanoate specifically binds to the LDL receptor-binding domain of PCSK9, blocks the interaction between PCSK9 and LDL receptor, prevents PCSK9 from degrading LDL receptors on the surface of hepatocytes, thereby increasing the number of available LDL receptors on hepatocyte surface, enhancing the hepatic clearance efficiency of low-density lipoprotein cholesterol (LDL-C) in the blood, and achieving potent lipid-lowering effects^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2861205-06-1
Peso molecular 1722.09
Fòrmula C₉₂H₁₂₉FN₁₄O₁₇
Synonyms

MK-0616 (decanoate)
Sequence

Ala-{Dpr}-Phe-Trp-Pro-Thr-Tyr-Pro(Covalent bridge:Phe3-Pro5,Ala1-Trp4,Trp4-Pro8,Ala1-Pro8,D-Dpr2)
Sequence Shortening

A-{Dpr}-FWPTYP(Covalent bridge:Phe3-Pro5,Ala1-Trp4,Trp4-Pro8,Ala1-Pro8,D-Dpr2)
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Elbahloul MA, et al. The Oral PCSK9 inhibitor enlicitide for hypercholesterolemia. Eur J Intern Med. 2026 Mar 14:106835.
[Content Brief]

[2]. Merck. "Merck’s Enlicitide Decanoate, an Investigational Oral PCSK9 Inhibitor, Significantly Reduced LDL-C in Phase 3 CORALreef Lipids Trial." Merck, 8 Nov. 2025.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Enlicitide (decanoate)

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Enlicitide (decanoate)

Actividad biológica

Chemical Information

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Referencias

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Enlicitide (decanoate) Related Classifications

HY-W1126955 Related Classifications